DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS

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	DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS
	Arnsten AFT*1; Cai JX 2; Murphy BL 1; Goldmanrakic PS 1
	1994
发表期刊	PSYCHOPHARMACOLOGY
ISSN	0033-3158
卷号	116 期号:2 页码:143-151
摘要	Dopamine (DA) D-1 receptor compounds were examined in monkeys for effects on the working memory functions of the prefrontal cortex and on the fine motor abilities of the primary motor cortex. The D-1 antagonist, SCH23390, the partial D-1 agonist, SKF38393, and the full D-1 agonist, dihydrexidine, were characterized in young control monkeys, and in aged monkeys with naturally occurring catecholamine depletion. In addition, SKF38393 was tested in young monkeys experimentally depleted of catecholamines with chronic reserpine treatment. Injections of SCH23390 significantly impaired the memory performance of young control monkeys, but did not impair aged monkeys with presumed catecholamine depletion. Conversely, the partial agonist, SKF38393, improved the depleted monkeys (aged or reserpine-treated) but did not improve young control animals. The full agonist, dihydrexidine, did improve memory performance in young control monkeys, as well as in a subset of aged monkeys. Consistent with D, receptor mechanisms, agonist-induced improvements were blocked by SCH23390. Drug effects on memory performance occurred independently of effects on fine motor performance. These results underscore the importance of DA D-1 mechanisms in cognitive function, and provide functional evidence of DA system degeneration in aged monkeys. Finally, high doses of D-1 agonists impaired memory performance in aged monkeys, suggesting that excessive D-1 stimulation may be deleterious to cognitive function.
资助者	This research was supported by PHS grants AG06036 to Dr. Arnsten, and MH44866 to Dr. Goldman-Rakic, and by the Scientific Foundation of Academia Sinica, No: K.P. 85 to Dr. Cai. ; This research was supported by PHS grants AG06036 to Dr. Arnsten, and MH44866 to Dr. Goldman-Rakic, and by the Scientific Foundation of Academia Sinica, No: K.P. 85 to Dr. Cai.
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收录类别	SCI
语种	英语
资助者	This research was supported by PHS grants AG06036 to Dr. Arnsten, and MH44866 to Dr. Goldman-Rakic, and by the Scientific Foundation of Academia Sinica, No: K.P. 85 to Dr. Cai. ; This research was supported by PHS grants AG06036 to Dr. Arnsten, and MH44866 to Dr. Goldman-Rakic, and by the Scientific Foundation of Academia Sinica, No: K.P. 85 to Dr. Cai.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5089
专题	其他
作者单位	1.Section of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510-8001, USA 2.Kunming Institute of Zoology, Academia Sinica, Kunming, China
推荐引用方式 GB/T 7714	Arnsten AFT*,Cai JX,Murphy BL,et al. DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS[J]. PSYCHOPHARMACOLOGY,1994,116(2):143-151.
APA	Arnsten AFT*,Cai JX,Murphy BL,&Goldmanrakic PS.(1994).DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS.PSYCHOPHARMACOLOGY,116(2),143-151.
MLA	Arnsten AFT*,et al."DOPAMINE D-1 RECEPTOR MECHANISMS IN THE COGNITIVE PERFORMANCE OF YOUNG-ADULT AND AGED MONKEYS".PSYCHOPHARMACOLOGY 116.2(1994):143-151.

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