Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys

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	Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys
	Cai JX 1; Arnsten AFT 2
	1997
发表期刊	JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
ISSN	0022-3565
卷号	283 期号:1 页码:183-189
摘要	With advancing age, monkeys develop deficits in spatial working memory resembling those induced by lesions of the prefrontal cortex (PFC). Aged monkeys also exhibit marked loss of dopamine from the PFC, a transmitter known to be important for proper PFC cognitive function. Previous results suggest that D1 agonist treatment can improve spatial working memory abilities in aged monkeys. However, this research was limited by the use of drugs with either partial agonist actions or significant D2 receptor actions. In our study, the selective dopamine D1 receptor full agonists A77636 and SKF81297 were examined in aged monkeys for effects on the working memory functions of the PFC. Both compounds produced a significant, dose-related effect on delayed response performance without evidence of side effects: low doses improved performance although higher doses impaired or had no effect on performance. Both the improvement and impairment in performance were reversed by pretreatment with the D1 receptor antagonist, SCH23390. These findings are consistent with previous results demonstrating that there is a narrow range of D1 receptor stimulation for optimal PFC cognitive function, and suggest that very low doses of D1 receptor agonists may have cognitive-enhancing actions in the elderly.
资助者	This work was supported by The Chinese Academy of Sciences KP-85, KY-85 and NSFC to J.X.C. and Public Health Service Grant AG06036 to A.F.T.A. ; This work was supported by The Chinese Academy of Sciences KP-85, KY-85 and NSFC to J.X.C. and Public Health Service Grant AG06036 to A.F.T.A.
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收录类别	SCI
语种	英语
资助者	This work was supported by The Chinese Academy of Sciences KP-85, KY-85 and NSFC to J.X.C. and Public Health Service Grant AG06036 to A.F.T.A. ; This work was supported by The Chinese Academy of Sciences KP-85, KY-85 and NSFC to J.X.C. and Public Health Service Grant AG06036 to A.F.T.A.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5125
专题	其他
作者单位	1.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, China 650223 2.Section of Neurobiology, Yale Medical School, New Haven, Connecticut
推荐引用方式 GB/T 7714	Cai JX,Arnsten AFT. Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,1997,283(1):183-189.
APA	Cai JX,&Arnsten AFT.(1997).Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,283(1),183-189.
MLA	Cai JX,et al."Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283.1(1997):183-189.

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