Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment

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	Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment
	Ye JW 1; Cai JX 2; Wang LM 1; Tang XC*1
	1999
发表期刊	JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
ISSN	0022-3565
卷号	288 期号:2 页码:814-819
合作性质	其它
摘要	Our previous studies demonstrated that huperzine A, a reversible and selective acetylcholinesterase inhibitor, exerts beneficial effects on memory deficits in various rodent models of amnesia. To extend the antiamnesic action of huperzine A to nonhuman primates, huperzine A was evaluated for its ability to reverse the deficits in spatial memory produced by scopolamine in young adult monkeys or those that are naturally occurring in aged monkeys using a delayed-response task. Scopolamine, a muscarinic receptor antagonist, dose dependently impaired performance with the highest dose (0.03 mg/kg, i.m.) producing a significant reduction in choice accuracy in young adult monkeys. The delayed performance changed from an average of 26.8/30 trials correct on saline control to an average of 20.2/30 trials correct after scopolamine administration. Huperzine A (0.01-0.1 mg/kg, i.m.) significantly reversed deficits induced by scopolamine in young adult monkeys on a delayed-response task; performance after an optimal dose (0.1 mg/kg) averaged 25.0/30 correct. In four aged monkeys, huperzine A (0.001-0.01 mg/kg, i.m.) significantly increased choice accuracy from 20.5/30 on saline control to 25.2/30 at the optimal dose (0.001 mg/kg for two monkeys and 0.01 mg/kg for the other two monkeys). The beneficial effects of huperzine A on delayed-response performance were long lasting; monkeys remained improved for about 24 h after a single injection of huperzine A. This study extended the findings that huperzine A improves the mnemonic performance requiring working memory in monkeys, and suggests that huperzine A may be a promising agent for clinical therapy of cognitive impairments in patients with Alzheimer's disease.
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5155
专题	其他
作者单位	1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, P.R. China
推荐引用方式 GB/T 7714	Ye JW,Cai JX,Wang LM,et al. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,1999,288(2):814-819.
APA	Ye JW,Cai JX,Wang LM,&Tang XC*.(1999).Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,288(2),814-819.
MLA	Ye JW,et al."Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 288.2(1999):814-819.

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