Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships

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	Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships
	Yang J 1; Liu CQ*1,2; jfhuang@public.km.yn.cn
	2000
发表期刊	JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
ISSN	0166-1280
卷号	532 期号:X 页码:1-10
合作性质	其它
摘要	Five models for human interleukin-7 (HIL-7), HIL-9, HIL-13, HIL-15 and HIL-17 have been generated by SYBYL software package. The primary models were optimized using molecular dynamics and molecular mechanics methods. The final models were optimized using a steepest descent algorithm and a subsequent conjugate gradient method. The complexes with these interleukins and the common gamma chain of interleukin-2 receptor (IL-2R) were constructed and subjected to energy minimization. We found residues, such as Gln127 and Tyr103, of the common gamma chain of IL-2R are very important. Other residues, e.g. Lys70, Asn128 and Glu162, are also significant. Four hydrophobic grooves and two hydrophilic sites converge at the active site triad of the gamma chain. The binding sites of these interleukins interaction with the common gamma chain exist in the first helical and/or the fourth helical domains. Therefore, we conclude that these interleukins binds to the common gamma chain of IL-2R by the first and the fourth helix domain. Especially at the binding sites of some residues (lysine, arginine, asparagine, glutamic acid and aspartic acid), with a discontinuous region of the common gamma chain of IL-2R, termed the interleukins binding sites (103-210). The study of these sites can be important for the development of new drugs.
关键词	Interleukin Molecular Modeling Sharing The Common Gamma Chain Of Il-2r Interaction
资助者	This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418
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收录类别	SCI
语种	英语
资助者	This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418 ; This work was supported by the National Natural Science Foundation of China, No.39770418
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5163
专题	其他细胞与分子进化开放实验室
通讯作者	jfhuang@public.km.yn.cn
作者单位	1.Laboratory of Cell and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming YN650223, People’s Republic of China 2.Modern Biological Center, Yunnan University, Kunming YN650091, People’s Republic of China
推荐引用方式 GB/T 7714	Yang J,Liu CQ*,jfhuang@public.km.yn.cn. Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2000,532(X):1-10.
APA	Yang J,Liu CQ*,&jfhuang@public.km.yn.cn.(2000).Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,532(X),1-10.
MLA	Yang J,et al."Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 532.X(2000):1-10.

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