Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchid testis in rat and rhesus monkey

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	Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchid testis in rat and rhesus monkey
	Guo CX 1; Hu ZY 1; Zou RJ 2; Mu XM 1; Liu YX*1
	2000
发表期刊	CHINESE SCIENCE BULLETIN
ISSN	1001-6538
卷号	45 期号:8 页码:720-725
合作性质	其它
摘要	Expression and cellular localization of orphan receptor TR2 mRNA in relation to germ cell apoptosis in cryptorchid testes of rat and rhesus monkey have been studied by using in situ hybridization and in situ 3'-end labeling of DNA fragments (TUNEL). The results show that: (i) TR2 mRNA is specifically expressed in the germ cells, mainly in the spermatocytes, round and elongated spermatids. The expression level of TR2 mRNA varies with the seminiferous cycle, (ii) In the rat cryptorchid testes on days 3 and 5 after the surgery, the germ cells began to undergo apoptosis with no evident decrease in TR2 mRNA level. On day 7.5, however, most germ cells underwent apoptosis, while the expression level of TR2 mRNA declined markedly, and TR2 mRNA was rarely expressed on day 10 thereafter. (iii) On days 15 and 20 of the cryptorchid testes of rhesus monkey, TR2 mRNA was only expressed in a few of primary spermatocytes and the mRNA was almost undetectable on days 30, 45, 60. These results suggest that TR2 mRNA probably plays an important role in spermatogenesis and germ cell apoptosis.
关键词	Orphan Receptor Tr2 In Situ Hybridization Cryptorchidism Spermatogenesis Apoptosis
资助者	This work was supported by the fund of "Pang-Dung Project" and the Chinese Academy of Sciences and the National Natural Science Foundation of China (Grant Nos. 30870368 and 39670285). ; This work was supported by the fund of "Pang-Dung Project" and the Chinese Academy of Sciences and the National Natural Science Foundation of China (Grant Nos. 30870368 and 39670285).
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收录类别	SCI
语种	英语
资助者	This work was supported by the fund of "Pang-Dung Project" and the Chinese Academy of Sciences and the National Natural Science Foundation of China (Grant Nos. 30870368 and 39670285). ; This work was supported by the fund of "Pang-Dung Project" and the Chinese Academy of Sciences and the National Natural Science Foundation of China (Grant Nos. 30870368 and 39670285).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5171
专题	其他
作者单位	1.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Guo CX,Hu ZY,Zou RJ,et al. Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchid testis in rat and rhesus monkey[J]. CHINESE SCIENCE BULLETIN,2000,45(8):720-725.
APA	Guo CX,Hu ZY,Zou RJ,Mu XM,&Liu YX*.(2000).Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchid testis in rat and rhesus monkey.CHINESE SCIENCE BULLETIN,45(8),720-725.
MLA	Guo CX,et al."Expression and regulation of orphan receptor TR2 mRNA in germ cells of cryptorchid testis in rat and rhesus monkey".CHINESE SCIENCE BULLETIN 45.8(2000):720-725.

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