On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China

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	On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China
	Yang RG 1; Xia XS 2; Kusagawa S 1; Zhang CY 2; Ben KL2; Takebe Y1; kben@21cn.com ; caijx@mail.kiz.ac.cn
	2002
发表期刊	AIDS
ISSN	0269-9370
卷号	16 期号:10 页码:1401-1407
合作性质	其它
摘要	Objectives: To investigate the molecular epidemiology of HIV in China's Yunnan Province, where the initial HIV-1 outbreak among injecting drug users (IDU) occurred in 1989, and to analyse the genesis and interrelationship of the epidemic with that in surrounding areas. Design: A molecular epidemiological investigation was conducted among IDU in three prefectures in Yunnan Province, including Wenshan (east), Honghe (southeast) and Dehong (west). Methods: Thirty-nine specimens were collected from consenting IDU in 2000-2001. The nucleotide sequences of 2.6 kb gag-RT and 340 base pair (bp) env (C2/V3) regions were determined. Phylogenetic tree and recombination breakpoint analyses were performed. Results: The circulating recombinant form (CRF), CRF08_BC, predominated in east Yunnan near Guangxi Province (89% in Wenshan and 81% in Honghe), whereas it was not detected in Dehong(0/14) in the west. In contrast, 71% (10/14) of the Dehong isolates were unique recombinant forms (URF), mostly between subtypes B' (Thailand variant of subtype B) and C, with distinct profiles of recombination breakpoints. The subtype B' accounts for the remaining 29% (4/14) of Dehong isolates. Interestingly, two Honghe isolates (2/16) shared some of the precise B'/C recombination breakpoints with CRF07_BC. Conclusion: New recombinant strains are arising continually in west Yunnan near the Myanmar border. Some appeared to be secondary recombinants derived from CRF07_BC that had further recombined with other strains. The uneven distribution of subtypes, CRF and URF, suggests the presence of independent transmission networks and clusters among IDU in Yunnan.
关键词	China Circulating Recombinant Forms (Crf) Hiv-1 Intersubtype Recombinants Injecting Drug Users Molecular Epidemiology Unique Recombinant Forms (Urf) Yunnan Province
资助者	This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP.
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收录类别	SCI
语种	英语
资助者	This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP. ; This study was supported by the grants from the Ministry of Health, Labour and Welfare, the Ministry of Education, Science and Technology, and the Japanese Foundation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowship from JFAP.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5237
专题	其他
通讯作者	kben@21cn.com; caijx@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, The People’s Republic of China
推荐引用方式 GB/T 7714	Yang RG,Xia XS,Kusagawa S,et al. On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China[J]. AIDS,2002,16(10):1401-1407.
APA	Yang RG.,Xia XS.,Kusagawa S.,Zhang CY.,Ben KL*.,...&caijx@mail.kiz.ac.cn.(2002).On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China.AIDS,16(10),1401-1407.
MLA	Yang RG,et al."On-going generation of multiple forms of HIV-1 intersubtype recombinants in the Yunnan Province of China".AIDS 16.10(2002):1401-1407.

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