The comparative analysis of the energies of conjugated triple base triplets and their applications

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	The comparative analysis of the energies of conjugated triple base triplets and their applications
	Liu SQ 1; Yang J 1; Bai CL 2; Liu CQ*1,3; tbrg@public.km.yn.cn
	2002
发表期刊	JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
ISSN	0166-1280
卷号	578 期号:X 页码:215-219
产权排序	The comparative analysis of the energies of conjugated triple base triplets and their applications
摘要	We built 64 sets of 3D models of DNA triplex base triplets (TBT) and minimized their energies. The TBTs were divided into 32 pairs of conjugated ones on the basis of their sequence characteristic, and the energies of each pair of them were compared and analyzed, the results showed: (i) The duplex DNA of which any strand contains at least a couple of A or T, has a preference for selecting the oligodeoxyribonucleic acid (ODN) strand containing abundant T to form TBT. (ii) The duplex DNA of which any strand contains at least a couple of G or C has a preference for selecting ODN containing abundant G to form symmetric antiparallel TBT, but selecting ODN containing abundant C to form asymmetric parallel TBT. (iii) The duplex DNA of which any strand contains only one of A, T, G or C has a preference for selecting ODN containing abundant pyrimidines (T or C) to form antiparallel TBT. Additionally, two examples of TBTs applications, in designing ODN to form triplex with duplex were presented. The energy calculation result revealed that 15-TCG is the best ligand of the HIV PPT duplex. The comparative analysis of energies of the conjugated TBTs provides directive significance for designing ODN strand that is easy to form triplex in theory. (C) 2002 Elsevier Science B.V. All rights reserved.
部门归属	其他
关键词	Conjugated Tbt Energy Comparative Analysis Applications
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收录类别	SCI
资助项目	The comparative analysis of the energies of conjugated triple base triplets and their applications
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5251
专题	其他细胞与分子进化重点实验室
通讯作者	tbrg@public.km.yn.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Lab Cellular & Mol Evolut, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100081, Peoples R China 3.Yunnan Univ, Modern Biol Ctr, Kunming 650091, Peoples R China
推荐引用方式 GB/T 7714	Liu SQ,Yang J,Bai CL,et al. The comparative analysis of the energies of conjugated triple base triplets and their applications[J]. JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,2002,578(X):215-219.
APA	Liu SQ,Yang J,Bai CL,Liu CQ*,&tbrg@public.km.yn.cn.(2002).The comparative analysis of the energies of conjugated triple base triplets and their applications.JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM,578(X),215-219.
MLA	Liu SQ,et al."The comparative analysis of the energies of conjugated triple base triplets and their applications".JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM 578.X(2002):215-219.

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