Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features

	Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features
	Yu MC 1,2; Cao XM 1; Xu JJ 1; Wang XL 1; Yang J 1; Wang XH 3; Ben KL[*]1,2; kben@mail.kiz.ac.cn
	2003
发表期刊	IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
ISSN	0892-3973
卷号	25 期号:4 页码:627-643
合作性质	其它
摘要	Testosterone undecanoate (TU) is under phase III clinical trial as a hormonal male contraceptive in China. Sex hormones can modulate the immune system. Female hormonal contraceptives may affect SIV/HIV-1 transmission. To evaluate the safety of TU and to understand whether long-term use of TU for a male contraceptive affects users' immunological features, adult male rats were treated for a 32-week TU-treated phase at the dose of 20 mg TU/kg body weight and a 24-week recovery phase. The reproductive and immunological parameters of 4-6 rats in each subgroup were examined at the stated time point. The mean sperm count and viability in the treated rats were significantly suppressed (p < 0.01). In the TU-treated group: the mean blood leukocyte and lymphocyte counts; the proliferation indexes of T cells from peripheral blood mononuclear cells (PBMC) and spleen; and, of B cells from spleen, as well as the mean counts of blood T, NK, and B cells decreased in comparison with those of control group. These decreases were not significant (p > 0.01). Similarly, the mean serum IgM, IgG, and IgA levels and complement activity in TU-treated rats were lower than those in control group (p > 0.01), and the changes in the antibody levels of the examined genital secretions were not significant (p > 0.01). The changes in the thickness of urethra epithelium, and in secretory component (SC) expression in genitals were not observed in the treated group. These results demonstrated that long-term supraphysiological TU injection did not obviously affect the examined rat immunological parameters.
关键词	Testosterone Undecanoate Male Contraceptive Immunological Parameters Epithelium Thickness Secretory Component Rats
资助者	This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M).
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收录类别	SCI
语种	英语
资助者	This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M). ; This work was supported by Applied and Basic Research Foundation of Yunnan (98C112M).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5261
专题	科研部门_分子免疫药理学（郑永唐）
通讯作者	kben@mail.kiz.ac.cn
作者单位	1.Laboratory for Molecular and Cell Immunology, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, P.R. China 2.Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China 3.Jiangsu Institute for Family Planning, Nanjing, Jiangsu, P.R. China
推荐引用方式 GB/T 7714	Yu MC,Cao XM,Xu JJ,et al. Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features[J]. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,2003,25(4):627-643.
APA	Yu MC.,Cao XM.,Xu JJ.,Wang XL.,Yang J.,...&kben@mail.kiz.ac.cn.(2003).Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features.IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,25(4),627-643.
MLA	Yu MC,et al."Effects of testosterone undecanoate as a male contraceptive candidate on rat immunological features".IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 25.4(2003):627-643.

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