Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor

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	Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor
	Sun QY*1; Chen G 2; Guo H 2; Chen S 2; Wang WY 1; Xiong YL 1; sunqy@hotmail.com
	2003
发表期刊	TOXICON
ISSN	0041-0101
卷号	42 期号:3 页码:257-262
合作性质	其它
摘要	A highly active cobra venom factor (CVF) was isolated from the venom of Naja kaouthia by sequential column chromatography. It displays strong anticomplementary activity, and has 1515 U of anticomplementary activity per mg protein. A single dose of 0.1 mg/kg CVF given i.v. to rats completely abrogated complement activity for nearly 5 days. Given 0.02 mg/kg of CVF, the complement activity of rats was reduced by more than 96.5% in 6 h. In guinea pig-to-rat heart transplant model, rats treated with a single dose of 0.05 mg/kg CVF had significantly prolonged xenograft survival (56.12+/-6.27 h in CVF-treated rats vs. 0.19+/-0.07 h in control rats, P<0.001).
关键词	Cobra Venom Factor Complement Guinea Pig-to-rat Model Heart Transplantation Xenotransplantation
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5269
专题	其他
通讯作者	sunqy@hotmail.com
作者单位	1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Institute of Organ Transplantation, the Affiliated Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430030, China
推荐引用方式 GB/T 7714	Sun QY*,Chen G,Guo H,et al. Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor[J]. TOXICON,2003,42(3):257-262.
APA	Sun QY*.,Chen G.,Guo H.,Chen S.,Wang WY.,...&sunqy@hotmail.com.(2003).Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor.TOXICON,42(3),257-262.
MLA	Sun QY*,et al."Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor".TOXICON 42.3(2003):257-262.

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