In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis

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	In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis
	Xie JP 1,2; Yue J 1,3; Xiong YL 4; Wang WY 4; Yu SQ 1; Wang HH*1; jianpingxie@yahoo.com
	2003
发表期刊	INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
ISSN	0924-8579
卷号	22 期号:2 页码:172-174
合作性质	其它
摘要	The recent re-emergence of tuberculosis, especially the multidrug-resistant cases, has highlighted the importance of screening effective novel drugs against Mycobacterium tuberculosis. In this study, the in vitro activities of small peptides isolated from snake venom were investigated against multidrug-resistant M. tuberculosis. Minimum inhibitory concentrations (MICs) were determined by the Bactec TB-460 radiometric method. A small peptide with the amino acid sequence ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGG (designated as vgf-1) from Naja atra (isolated from Yunnan province of China) venom had in vitro activity against clinically isolated multidrug-resistant strains of M. tuberculosis. The MIC was 8.5 mg/l. The antimycobacterial domain of this 60aa peptide is under investigation. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
关键词	Mycobacterium Tuberculosis Multidrug Resistance Snake Venom Small Peptide Naja Atra
资助者	The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03).
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收录类别	SCI
语种	英语
资助者	The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5271
专题	其他
通讯作者	jianpingxie@yahoo.com
作者单位	1.School of Life Science, Institute of Genetics, Fudan University, Shanghai 200433, People’s Republic of China 2.School of Life Science, Institute of Modern Biopharmaceuticals, Southwest Normal University, Chongqing 400715, People’s Republic of China 3.Shanghai Pulmonary Hospital, Shanghai 200433, People’s Republic of China 4.Laboratory of Animal Toxin, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China
推荐引用方式 GB/T 7714	Xie JP,Yue J,Xiong YL,et al. In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2003,22(2):172-174.
APA	Xie JP.,Yue J.,Xiong YL.,Wang WY.,Yu SQ.,...&jianpingxie@yahoo.com.(2003).In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,22(2),172-174.
MLA	Xie JP,et al."In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 22.2(2003):172-174.

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