KMS KUNMING INSTITUTE OF ZOOLOGY.CAS
| Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China | |
| Yang RG1; Kusagawa S1; Zhang CY2; Xia XS2; Ben KL2; Takebe Y*1; takebe@nih.go.jp | |
| 2003 | |
| 发表期刊 | JOURNAL OF VIROLOGY
 |
| ISSN | 0022-538X |
| 卷号 | 77期号:1页码:685-695 |
| 合作性质 | 其它 |
| 摘要 | We identified a new class of human immunodeficiency virus type 1 (HIV-1) recombinants (00CN-HH069 and 00CN-HH086) in which further recombination occurred between two established circulating recombinant forms (CRFs). These two isolates were found among 57 HIV-1 samples from a cohort of injecting drug users in eastern Yunnan Province of China. Informative-site analysis in conjunction with bootscanning plots and exploratory tree analysis revealed that these two strains were closely related mosaics comprised of CRF07_BC and CRF08_BC, which are found in China. The genotype screening based on gag-reverse transcriptase sequences if 57 samples from eastern Yunnan identified 47 CRF08_BC specimens (82.5%), 5 CRF07_BC specimens (8.8%), and 3 additional specimens with the novel recombinant structure. These new "second-generation" recombinants thus constitute a substantial proportion (5 of 57; 8.8%) of HIV-1 strains in this population and may belong to a new but yet-undefined class of CRF. This might be the first example of CRFs recombining with each other, leading to the evolution of second-generation inter-CRF recombinants. |
| 资助者 | This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. ; This study was supported by a grant-in-aid for AIDS research from the Ministry of Health, Labour and Welfare and the Ministry of Ed- ucation, Science and Technology of Japan and by the Japanese Foun- dation for AIDS Prevention (JFAP). R.Y. and S.K. are the recipients of Research Resident Fellowships from JFAP. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/5289 |
| 专题 | 其他 |
| 通讯作者 | takebe@nih.go.jp |
| 作者单位 | 1.Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Yang RG,Kusagawa S,Zhang CY,et al. Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China[J]. JOURNAL OF VIROLOGY,2003,77(1):685-695. |
| APA | Yang RG.,Kusagawa S.,Zhang CY.,Xia XS.,Ben KL.,...&takebe@nih.go.jp.(2003).Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China.JOURNAL OF VIROLOGY,77(1),685-695. |
| MLA | Yang RG,et al."Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China".JOURNAL OF VIROLOGY 77.1(2003):685-695. |
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