Extract of Ginkgo biloba leaves reverses yohimbine-induced spatial working memory deficit in rats

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	Extract of Ginkgo biloba leaves reverses yohimbine-induced spatial working memory deficit in rats
	Zhang M 1,2; Cai JX*1; caijx@post.kiz.ac.cn
	2005
发表期刊	BEHAVIOURAL PHARMACOLOGY
ISSN	0955-8810
卷号	16 期号:8 页码:651-656
合作性质	其它
摘要	Extract of Ginkgo biloba is used to alleviate age-related decline in cognitive function, which may be associated with the loss of catecholamines in the prefrontal cortex. The purpose of this study was to verify whether alpha-2 adrenergic activity is involved in the facilitative effects of extract of Ginkgo biloba on prefrontal cognitive function. Male Wistar rats were trained to reach criterion in the delayed alternation task (0, 25, and 50-s delay intervals). A pilot study found that 3 or 4 mg/kg of yohimbine (intraperitoneal) reduced the choice accuracy of the delayed alternation task in a dose and delay-dependent manner, without influencing motor ability or perseverative behaviour. Acute oral pre-treatment with doses of 50, 100, or 200 mg/kg (but not 25 mg/kg) of extract of Ginkgo biloba prevented the reduction in choice accuracy induced by 4 mg/kg yohimbine. These data suggest that the prefrontal cognition-enhancing effects of extract of Ginkgo biloba are related to its actions on alpha-2-adrenoceptors.
关键词	Ginkgo Biloba Norepinephrine Rat Spatial Working Memory
资助者	This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000).
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收录类别	SCI
语种	英语
资助者	This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000). ; This work was supported by Cooperative Program between Yunnan Province and Chinese Academy of Sciences (2004yk-02) and National Basic Research Program (G1999054000).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5341
专题	其他
通讯作者	caijx@post.kiz.ac.cn
作者单位	1.Kunming Institute of Zoology 2.Graduate School Chinese Academy of Sciences, China
推荐引用方式 GB/T 7714	Zhang M,Cai JX*,caijx@post.kiz.ac.cn. Extract of Ginkgo biloba leaves reverses yohimbine-induced spatial working memory deficit in rats[J]. BEHAVIOURAL PHARMACOLOGY,2005,16(8):651-656.
APA	Zhang M,Cai JX*,&caijx@post.kiz.ac.cn.(2005).Extract of Ginkgo biloba leaves reverses yohimbine-induced spatial working memory deficit in rats.BEHAVIOURAL PHARMACOLOGY,16(8),651-656.
MLA	Zhang M,et al."Extract of Ginkgo biloba leaves reverses yohimbine-induced spatial working memory deficit in rats".BEHAVIOURAL PHARMACOLOGY 16.8(2005):651-656.

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