Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation

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	Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation
	Zhang KL 1; Luo JC 1; Liu CQ*2,3,4; liucq@ynu.edu.cn
	2005
发表期刊	JOURNAL OF MOLECULAR STRUCTURE
ISSN	0166-1280
卷号	715 期号:1-3 页码:15-20
合作性质	其它
摘要	It is extremely difficult to explore mRNA folding structure by biological experiments. In this report, we use stochastic sampling and folding simulation to test the existence of the stable secondary structural units of-mRNA, look for the folding units, and explore the probabilistic stabilization of the units. Using this method, We made simulations for all possible local optimum secondary structures of a single strand mRNA within a certain range, and searched for the common parts of the secondary structures. The consensus secondary structure units (CSSUs) extracted from the above method are mainly hairpins, with a few single strands. These CSSUs suggest that the mRNA folding units could be relatively stable and could perform specific biological function. The significance of these observations for the mRNA folding problem in general is also discussed.
关键词	Mrna Secondary Structure Segments (Ssss) Consensus Secondary Structure Units (Cssus) Stochastic Sampling Folding Simulation
资助者	This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863.
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收录类别	SCI
语种	英语
资助者	This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863. ; This work is supported in part by the National Natural Science Foundation of China, the Mathematics Tian Yuan Foundation (A0324101), the National Key Basic Research Program (2003CB715900) and grants from 863.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5347
专题	其他
通讯作者	liucq@ynu.edu.cn
作者单位	1.Center of Bioinformatics, College of Life Science and National Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, Beijing 100871, China 2.Modern Biological Center, Yunnan University, Kunming 650091, China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Center for Theoretical Biology, Peking University, Beijing 100871, China
推荐引用方式 GB/T 7714	Zhang KL,Luo JC,Liu CQ*,et al. Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation[J]. JOURNAL OF MOLECULAR STRUCTURE,2005,715(1-3):15-20.
APA	Zhang KL,Luo JC,Liu CQ*,&liucq@ynu.edu.cn.(2005).Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation.JOURNAL OF MOLECULAR STRUCTURE,715(1-3),15-20.
MLA	Zhang KL,et al."Exploring consensus mRNA secondary (folding) structure units by stochastic sampling and folding simulation".JOURNAL OF MOLECULAR STRUCTURE 715.1-3(2005):15-20.

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