Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic

KIZ OpenIR > 其他

	Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic
	Li XJ 1,2; Kusagawa S 1; Xia XS 3; Yang CJ 1,4; Wang QQ 1,2; Yokota Y 1; Hoshina Y 1; Onogi T 1; Nohtomi K 1; Imamura Y 1; Shiino T 1; Yang RG 1,2; Yamamoto N 1; Ben KL 5,6; Takebe Y*1; takebe@nih.go.jp
	2005
发表期刊	AIDS RESEARCH AND HUMAN RETROVIRUSES
ISSN	0889-2229
卷号	21 期号:11 页码:977-980
合作性质	其它
摘要	Molecular epidemiological investigation was conducted among injecting drug users (IDUs) (n = 11) and heterosexuals (n = 15) in Kunming, Yunnan Province of China. HIV-1 genotypes were determined based on the nucleotide sequences of 2.6-kb gag-RT region. The distribution of genotypes among IDUs was as follows: CRF07_BC (5/11) and CRF08_BC (5/11); subtype B' (1/11). Similarly, a majority of Kunming heterosexuals (14/15) were infected with CRF07_BC (4/15), CRF08_BC (6/15), or subtype B' (4/15), known to predominate among IDUs in China. This contrasts with trends in the coastal regions of China and surrounding southeastern Asian countries, where CRF01_AE predominates among heterosexuals. The heterosexual HIV-1 epidemic in Kunming thus appears to derive from the local IDU epidemic. Of note, subtype B' was the most prevalent strain among heterosexuals before 1997, while CRF07_BC and CRF08_BC became predominant in 2002, indicating a transition of HIV-1 genotype distribution between the early and the more recent samples from Kunming heterosexuals.
资助者	This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation.
URL	查看原文
收录类别	SCI
语种	英语
资助者	This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation. ; This study was supported by grants from the Ministry of Health, Labour and Welfare, Ministry of Education, Science and Technology, and Japanese Foundation for AIDS Prevention (JFAP). X.-J. L. is a recipient of a Re- search Resident Fellowship from JFAP. C.Y. is a research fel- low of the Japan–China Medical Association. Q.W. is a Fellow of the Takeda Science Foundation.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5353
专题	其他
通讯作者	takebe@nih.go.jp
作者单位	1.Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. 2.Institute of Dermatology, Chinese Academy of Medical Sciences, 12 Jiangwangmiao Road, Nanjing 210042, The People’s Republic of China 3.Kunming University of Science and Technology, Kunming, Yunnan 650224, The People’s Republic of China 4.Yunnan Provincial Health and Anti-epidemic Center, 158 Dongsi Road, Kunming 650022, The People’s Republic of China 5.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, The People’s Republic of China 6.Kunming Chinaware Biotechnology, Yunnan 650106, The People’s Republic of China
推荐引用方式 GB/T 7714	Li XJ,Kusagawa S,Xia XS,et al. Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic[J]. AIDS RESEARCH AND HUMAN RETROVIRUSES,2005,21(11):977-980.
APA	Li XJ.,Kusagawa S.,Xia XS.,Yang CJ.,Wang QQ.,...&takebe@nih.go.jp.(2005).Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic.AIDS RESEARCH AND HUMAN RETROVIRUSES,21(11),977-980.
MLA	Li XJ,et al."Molecular epidemiology of the heterosexual HIV-1 transmission in Kunming, Yunnan Province of China suggests origin from the local IDU epidemic".AIDS RESEARCH AND HUMAN RETROVIRUSES 21.11(2005):977-980.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
200521977.pdf（167KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文