KMS KUNMING INSTITUTE OF ZOOLOGY.CAS
| Disconnection of the hippocampal-prefrontal cortical circuits impairs spatial working memory performance in rats | |
| Wang GW1,2,3; Cai JX*1,2; caijx@post.kiz.ac.cn | |
| 2006 | |
| 发表期刊 | BEHAVIOURAL BRAIN RESEARCH
 |
| ISSN | 0166-4328 |
| 卷号 | 175期号:2页码:329-336 |
| 合作性质 | 其它 |
| 摘要 | There is a unidirectional, ipsilateral and monosynaptic projection from the hippocampus to the prefrontal cortex. The cognitive function of hippocampal-prefrontal cortical circuit is not well established. In this paper, we use muscimol treated rats to investigate the roles of the hippocampal-prefrontal cortical circuits in spatial working memory, as assessed with a delayed spatial alternation task. First of all, the effect of muscimol on EEG power of infusion area was observed for confirmation of the dosage of muscimol to inhibit the function of infusion area. The results show that the EEG power of the ventral hippocampus and the prelimbic area of the prefrontal cortex were inhibited by local infusion of muscimol (0.5 microg in 0.25 microl PBS) into the above areas, respectively. Delayed alternation performance was significantly impaired when muscimol at this dosage was infused (1) bilaterally into the ventral hippocampus, (2) bilaterally into the prelimbic area, (3) unilaterally into the ventral hippocampus and simultaneously contralaterally into the prelimbic area. Infusion of muscimol either unilaterally into the ventral hippocampus or unilaterally into the prelimbic area did not impair delayed alternation performance. The present results suggest that any structures in this circuit is damaged or inhibited bilaterally, the spatial working memory will be disrupted. It means the hippocampal-prefrontal cortical circuit plays an important role in spatial working memory. |
| 部门归属 | 其他 |
| 关键词 | Hippocampus Prefrontal Cortex Hippocampal–prefrontal Cortical Circuit Spatial Working Memory Delayed Spatial Alternation Task T-maze Muscimol |
| 资助者 | This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. ; This work was sup- ported by the National Natural Science Foundation of China (30070251) and the National Basic Research Program of China (G1999054000) to Prof. J. X. Cai. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/5361 |
| 专题 | 其他 |
| 通讯作者 | caijx@post.kiz.ac.cn |
| 作者单位 | 1.Laboratory of Brain and Behaviour, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of Chinese Academy of Sciences, Beijing 100039, China 3.School of Life Sciences, Yunnan Normal University, Kunming, Yunnan 650092, China |
| 推荐引用方式 GB/T 7714 | Wang GW,Cai JX*,caijx@post.kiz.ac.cn. Disconnection of the hippocampal-prefrontal cortical circuits impairs spatial working memory performance in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2006,175(2):329-336. |
| APA | Wang GW,Cai JX*,&caijx@post.kiz.ac.cn.(2006).Disconnection of the hippocampal-prefrontal cortical circuits impairs spatial working memory performance in rats.BEHAVIOURAL BRAIN RESEARCH,175(2),329-336. |
| MLA | Wang GW,et al."Disconnection of the hippocampal-prefrontal cortical circuits impairs spatial working memory performance in rats".BEHAVIOURAL BRAIN RESEARCH 175.2(2006):329-336. |
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| 2006175329.pdf（390KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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