Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats

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	Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats
	Wang GW 1,2,3,4; Cai JX*1,4; caijx@post.kiz.ac.cn
	2008
发表期刊	NEUROBIOLOGY OF LEARNING AND MEMORY
ISSN	1074-7427
卷号	90 期号:2 页码:365-373
摘要	Wistar rats, treated with the GABA(A) receptor agonist muscimol, were used to investigate the role of the hippocampal-prelimbic cortical (Hip-PLC) circuit in spatial learning in the Morris water maze task, and in passive avoidance learning in the step-through task. In the water maze task, animals were trained for three consecutive days and tested 24 h after the end of training. In the step-through task, the animals were trained once and tested 24 h after training. On the training days, daily infusion of muscimol (0.5 mu g/0.25 mu l) was given (1) bilaterally to the ventral hippocampus (vHip), (2) bilaterally to the prelimbic cortex (PLC), (3) to the unilateral vHip and the ipsilateral PLC, or (4) for disconnecting the Hip-PLC circuit, to both the unilateral vHip and the contralateral PLC 30 min before training. The results showed that inhibition of the vHip resulted in disruption of performance in both tasks. Inhibition of the PLC produced impaired water maze performance, but had no effect on the step-through task. Disconnection of the Hip-PLC circuit produced similar effects to PLC inhibition. However, simultaneous inhibition of the unilateral vHip and the ipsilateral PLC had little effect on performance of the water maze task. The results suggested that spatial learning depends on the Hip-PLC circuit, whereas passive avoidance learning is independent of this circuit.
部门归属	其他
关键词	Passive Avoidance Spatial Learning Wistar Rats Hippocampus Prefrontal Cortex Prelimbic Cortex
资助者	This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang.
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语种	英语
资助者	This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang. ; This work was supported by NSFC (30070251) and the 973 Program of China (G1999054000) to Prof. J.-X. Cai, and the Applied Basic Research Fund of Yunnan Province (2007C051M) and the Yunnan Normal University Natural Science Research Foun- dation for Young Scientists (2007) to Dr. G.-W. Wang.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5385
专题	其他
通讯作者	caijx@post.kiz.ac.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Lab Brain & Behav, Kunming 650223, Yunnan, Peoples R China 2.Yunnan Normal Univ, Sch Life Sci, Kunming 650092, Yunnan, Peoples R China 3.Fudan Univ, Inst Brain Sci, Inst Neurobiol, Shanghai 200032, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang GW,Cai JX*,caijx@post.kiz.ac.cn. Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2008,90(2):365-373.
APA	Wang GW,Cai JX*,&caijx@post.kiz.ac.cn.(2008).Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats.NEUROBIOLOGY OF LEARNING AND MEMORY,90(2),365-373.
MLA	Wang GW,et al."Reversible disconnection of the hippocampal-prelimbic cortical circuit impairs spatial learning but not passive avoidance learning in rats".NEUROBIOLOGY OF LEARNING AND MEMORY 90.2(2008):365-373.

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