Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys

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	Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys
	Yu S 1,2; Liu N 2; Zeng T 2,3; Tian SH 2,3; Chen NH 2,3; Zhou YF1; Ma YY2,3; zhouy@ustc.edu.cn ; yuanma0716@vip.sina.com
	2004
发表期刊	NEUROSCIENCE LETTERS
ISSN	0304-3940
卷号	366 期号:1 页码:58-62
合作性质	其它
摘要	Rapid eye movement (REM) is one of the most characteristic features of REM sleep, but the mechanisms underlying its regulation remain unclear. The present study aims to investigate whether the frontal eye field (FEF) is involved in the regulation of the rapid eye movements during REM sleep. To address this question, we ablated the FEF in four rhesus monkeys and observed the effects of the lesions on sleep architecture. After lesions, two adult monkeys did not show any lesion effect. However, in the other two adolescent monkeys, both the total duration and percentage of the rapid eye movements during REM sleep were decreased moderately. The result suggests that the relation between the FEF and the regulation of the rapid eye movements during REM sleep may be affected by age factor, also indicating that both the functions of the FEF and the mechanisms underlying the control of rapid eye movements during REM sleep might not be the same throughout the whole life span of an animal.
关键词	Eye Movement Rapid Eye Movement Sleep Frontal Eye Field Cortex Lesion Adolescence Rhesus Monkey
资助者	This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922.
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收录类别	SCI
语种	英语
资助者	This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922. ; This work was supported by Chinese Academy of Sci- ences Grants (KSCX2-SW for M.Y., KSCX2-SW-217 for Z.Y.), National Basic Research Program of China, Chi- nese Science Foundation (30070252), Program of Chinese Academy of Sciences (KJCX1-07) and NIH/NIA RO1 AG 17922.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5425
专题	认知障碍病理学科研部门_神经系统编码（胡新天）
通讯作者	zhouy@ustc.edu.cn; yuanma0716@vip.sina.com
作者单位	1.School of Life Sciences, University of Science and Technology of China, Hefei 230027, PR China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China
推荐引用方式 GB/T 7714	Yu S,Liu N,Zeng T,et al. Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys[J]. NEUROSCIENCE LETTERS,2004,366(1):58-62.
APA	Yu S.,Liu N.,Zeng T.,Tian SH.,Chen NH.,...&yuanma0716@vip.sina.com.(2004).Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys.NEUROSCIENCE LETTERS,366(1),58-62.
MLA	Yu S,et al."Age-related effects of bilateral frontal eye fields lesions on rapid eye movements during REM sleep in rhesus monkeys".NEUROSCIENCE LETTERS 366.1(2004):58-62.

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