| Improved spatial recognition memory in mice lacking adenosine A(2A) receptors | |
| Wang JH1,2,3; Ma YY*1; Van den Buuse M*3; yuanma0716@vip.sina.com; mvandenbuuse@mhri.edu.au | |
| 2006 | |
| 发表期刊 | EXPERIMENTAL NEUROLOGY
 |
| ISSN | 0014-4886 |
| 卷号 | 199期号:2页码:438-445 |
| 摘要 | Adenosine receptors play an important role in learning and memory as their antagonists have been found to facilitate learning and memory in various tasks in rodents. However, few studies have examined the effect of adenosine A2A receptor deficiency on cognition. In the present study, we therefore used the Y-maze, a simple two-trial recognition test to measure spatial recognition memory in mice lacking adenosine A2A receptors. The results showed that adenosine A2A receptor knockout mice had a higher percentage of novel arm visits as first choice than wild-type CD1 mice. Moreover, these mice showed longer duration of visits in the novel arm when compared with controls, suggesting that the lack of adenosine A2A receptors improved spatial recognition memory. On the other hand, mice lacking the adenosine A2A receptors had low scores in the number of arm visits, suggesting that they were hypoactive. In conclusion, these data suggest the involvement of adenosine receptors in modulating spatial recognition memory in mice, consistent with earlier findings using adenosine receptor antagonists. |
| 关键词 | Adenosine Knockout Wild Type Y-maze |
| 资助者 | National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). ; National Science Foundation of China (NSFC 30470553 and 30530270). |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/5447 |
| 专题 | 认知障碍病理学 科研部门_神经系统编码（胡新天） |
| 通讯作者 | yuanma0716@vip.sina.com; mvandenbuuse@mhri.edu.au |
| 作者单位 | 1.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu Kunming, Yunnan #650223, PR China 2.Graduate School of Chinese Academy of Sciences, Beijing, PR China 3.Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Victoria #3052, Australia |
| 推荐引用方式 GB/T 7714 | Wang JH,Ma YY*,Van den Buuse M*,et al. Improved spatial recognition memory in mice lacking adenosine A(2A) receptors[J]. EXPERIMENTAL NEUROLOGY,2006,199(2):438-445. |
| APA | Wang JH,Ma YY*,Van den Buuse M*,yuanma0716@vip.sina.com,&mvandenbuuse@mhri.edu.au.(2006).Improved spatial recognition memory in mice lacking adenosine A(2A) receptors.EXPERIMENTAL NEUROLOGY,199(2),438-445. |
| MLA | Wang JH,et al."Improved spatial recognition memory in mice lacking adenosine A(2A) receptors".EXPERIMENTAL NEUROLOGY 199.2(2006):438-445. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2006199438.pdf（209KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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