Effects of scopolamine on morphine-induced conditioned place preference in mice

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	Effects of scopolamine on morphine-induced conditioned place preference in mice
	Tan H 1,2,3,4; Liu N 1,2,3; Wilson FAW 1,2,3; Ma YY*1,2,3; yuanma@hotmail.com
	2007
发表期刊	ADDICTION BIOLOGY
ISSN	1355-6215
卷号	12 期号:3-4 页码:463-469
合作性质	其它
摘要	It is well known that the cholinergic system plays a crucial role in learning and memory. Psychopharmacological studies in humans and animals have shown that a systemic cholinergic blockade may induce deficits in learning and memory. Accumulated studies have indicated that learning and memory play an important role in drug addition. In the present study, in order to get a further understanding about the functions of the cholinergic system in drug-related learning and memory, we examined the effects of scopolamine (0.5, 1.0 and 2.0 mg/kg) on morphine-induced conditioned place preference (CPP). Two kinds of morphine exposure durations (4 days and 12 days) were used. The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days. However, in mice treated with morphine for 4 days, all doses of scopolamine did not inhibit morphine-induced CPP. The highest dose (2.0 mg/kg) of scopolamine even significantly delayed the extinction of morphine-induced CPP. Our results suggest that the effects of a systemic cholinergic blockade on morphine-induced CPP depend on the morphine exposure time.
关键词	Cholinergic System Conditioned Place Preference Learning And Memory Mice Morphine Scopolamine
资助者	This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance.
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收录类别	SCI
语种	英语
资助者	This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance. ; This study was supported by Key Technologies R&D Program (2006038022021), National Natural Science Foundation of China (NSFC 30470553 and 30530270), 973 program (2005CB522803), and the Chinese Acad- emy of Science Grants (KSCX2-SW-217-03). We thank Mr Sun for his assistance.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5459
专题	认知障碍病理学中国科学院昆明灵长类研究中心
通讯作者	yuanma@hotmail.com
作者单位	1.Kunming Institute of Zoology 2.Kunming Primate Research Center,Chinese Academy of Sciences, 3.Graduate University of Chinese Academy of Sciences, China 4.College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, China
推荐引用方式 GB/T 7714	Tan H,Liu N,Wilson FAW,et al. Effects of scopolamine on morphine-induced conditioned place preference in mice[J]. ADDICTION BIOLOGY,2007,12(3-4):463-469.
APA	Tan H,Liu N,Wilson FAW,Ma YY*,&yuanma@hotmail.com.(2007).Effects of scopolamine on morphine-induced conditioned place preference in mice.ADDICTION BIOLOGY,12(3-4),463-469.
MLA	Tan H,et al."Effects of scopolamine on morphine-induced conditioned place preference in mice".ADDICTION BIOLOGY 12.3-4(2007):463-469.

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