Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia

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	Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia
	Fu Y 1,2; Guo L 2; Zhang J 1; Chen Y 1; Wang X 1; Zeng T 1; Tian S 1; Ma Y*1,4,5; yuanma0716@vip.sina.com
	2008
发表期刊	EUROPEAN JOURNAL OF ANAESTHESIOLOGY
ISSN	0265-0215
卷号	25 期号:10 页码:826-833
合作性质	其它
摘要	Background and objectives: Pentobarbital and ketamine are commonly used in animal experiments, including studies on the effects of ageing on the central nervous system. The electroencephalogram is a sensitive measure of brain activity. The present study investigated, under anaesthesia induced by the two drugs, whether cortical electroencephalogram in aged rats differs from that in young rats. Methods: Electroencephalogram was recorded for young (2-3 months) and aged (15-17 months) rats before and during pentobarbital (40 mg kg(-1)) or ketamine (100 mg kg(-1)) anaesthesia. The relative power in five frequency bands (delta: 2-4Hz; theta: 4-8 Hz; alpha: 8-12 Hz; beta: 12-20 Hz; gamma: 20-100 Hz) was analysed, and then compared between the two age groups. Results: In both age groups, pentobarbital anaesthesia induced an increase in relative power in alpha and beta bands and a decrease in the theta band, but the degree of these power variations was more marked in aged rats. Ketamine anaesthesia increased relative power in the delta band and decreased that in the theta band; these effects were significantly different between the two age groups, with aged rats showing more markedly decreased power in the theta band. Conclusions: (a) Pentobarbital and ketamine modified cortical electrical activity in a different manner as a function of age; (b) the modification of electroencephalogram relative power with anaesthesia was identical in young and aged rats but quantitatively more marked in aged rats. These findings will be useful in designing experiments that assess pathological changes in the central nervous system during ageing.
关键词	Electroencephalogram Aged Rat Ketamine Pentobarbital Anaesthesia General
学科领域	Anesthesiology
资助者	This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2).
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收录类别	SCI
语种	英语
资助者	This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810,2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese-Finnish Inter- national Collaboration Project-Neuro (30621130076), theProgramofCASC(KSCX1-YW-R-33, YZ200737), the National Key Technologies R&D Program and the Yunnan Science and Technique Program (2006PT08-2).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5463
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	yuanma0716@vip.sina.com
作者单位	1.Chinese Academy of Sciences, Kunming Institute of Zoology, Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming, Yunnan 2.Graduate University of Chinese Academy of Sciences, Beijing 3.Chinese Academy of Medical Sciences, Institute of Medical Biology, Department of Viral Immunology, Kunming, Yunnan 4.Chinese Academy of Sciences, Kunming Primate Research Center, Kunming, Yunnan 5.Kunming Biomed International, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Fu Y,Guo L,Zhang J,et al. Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia[J]. EUROPEAN JOURNAL OF ANAESTHESIOLOGY,2008,25(10):826-833.
APA	Fu Y.,Guo L.,Zhang J.,Chen Y.,Wang X.,...&yuanma0716@vip.sina.com.(2008).Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia.EUROPEAN JOURNAL OF ANAESTHESIOLOGY,25(10),826-833.
MLA	Fu Y,et al."Differential effects of ageing on the EEG during pentobarbital and ketamine anaesthesia".EUROPEAN JOURNAL OF ANAESTHESIOLOGY 25.10(2008):826-833.

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