Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory

KIZ OpenIR > 认知障碍病理学

	Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory
	Zhang J 1,2,3; He J 1,2,3; Chen YM 1,2,3; Wang JH1,2,3; Ma YY1,2,4; wangjh@mail.kiz.ac.cn ; yuanma07l6@vip.sina.com
	2008
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
卷号	1230 期号:X 页码:150-157
合作性质	其它
摘要	In the present study, the interaction between morphine and the beta-adrenergic receptor antagonist, propranolol (PROP), in memory consolidation was investigated in a two-trial recognition Y-maze task. Four sets of Y-maze experiments were carried out in mice, with 2 and 4 h inter-trial intervals (ITI) and all drugs administered immediately after the training trials. In the first and second. sets of experiments, post-training administration of morphine (0.25 and 2.5 mg/kg) or PROP (2, 10 and 20 mg/kg) alone did not impair memory consolidation after a 2 h ITI. However, in the third and fourth sets of experiments, co-administration of these ineffective doses of morphine (0.25 and 2.5 mg/kg) and PROP (2, 10 and 20 mg/kg) disrupted memory consolidation after a 2 h ITI. Moreover, the relatively higher dose of morphine (2.5 mg/kg) plus the relatively higher doses of PROP (10 and 20 mg/kg) disrupted memory consolidation to a greater extent after a 2 h ITI. Locomotor activity was not affected by any of the drug treatments. Our data shows that morphine and PROP co-administration disrupts the consolidation of spatial recognition memory, suggesting that inactivation of the beta-adrenergic system may contribute to morphine-induced impairment of memory.
关键词	Beta-adrenoceptor Mice Cathelicidin Elapid Snake Molecular Cloning Phylogenetic Analysis
学科领域	Neurosciences
资助者	This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program.
收录类别	SCI
语种	英语
资助者	This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program. ; This study was supported by the National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), the 973 program (2005CB522803, 2007CB947703), the 863 program (O7013810), the Chinese- FinnishInternationalCollaborationProject-Neuro(30621130076), the Program of CASC (KSCX1-YW-R-33) and the National Key Technologies R&D Program.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5465
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室科研部门_神经系统编码（胡新天）中国科学院昆明灵长类研究中心
通讯作者	wangjh@mail.kiz.ac.cn; yuanma07l6@vip.sina.com
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, PR China 3.Graduate School of Chinese Academy of Sciences, Beijing, PR China 4.Kunming Biomed International, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Zhang J,He J,Chen YM,et al. Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory[J]. BRAIN RESEARCH,2008,1230(X):150-157.
APA	Zhang J.,He J.,Chen YM.,Wang JH.,Ma YY.,...&yuanma07l6@vip.sina.com.(2008).Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory.BRAIN RESEARCH,1230(X),150-157.
MLA	Zhang J,et al."Morphine and propranolol co-administration impair consolidation of Y-maze spatial recognition memory".BRAIN RESEARCH 1230.X(2008):150-157.

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