Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys

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	Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys
	Zhang J 6,7,8; Wang XS 6,7,8; Wang YC 9,10; Fu Y 6,7,8; Liang Z 9; Ma YY6,7; Leventhal AG9,10; audie.leventhal@m.cc.utah.edu ; yuanma0716@vip.sina.com
	2008
发表期刊	EUROPEAN JOURNAL OF NEUROSCIENCE
ISSN	0953-816X
卷号	28 期号:1 页码:201-207
合作性质	其它
摘要	Human visual function declines with age. Much of this decline is mediated by changes in the central visual pathways. In this study we compared the spatial and temporal sensitivities of striate cortical cells in young and old paralysed macaque monkeys. Extracellular single-unit recordings were employed. Our results show that cortical neurons in old monkeys exhibit lower optimal spatial and temporal frequencies, lower spatial resolution and lower high temporal frequency cut-offs than do cells in young adult monkeys. These changes in old monkeys are accompanied by increased visually evoked responses, increased spontaneous activities and decreased signal-to-noise ratios. The increased excitability of cells in old animals is consistent with an age-related degeneration of intracortical inhibition. The degradation of spatial and temporal function in old striate cortex should contribute to the decline in visual function that accompanies normal aging.
关键词	Aging Central Visual Pathway Degradation Intracortical Inhibition Spatial And Temporal Sensitivities Visual Function
学科领域	Neurosciences
资助者	This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703)
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收录类别	SCI
语种	英语
资助者	This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703) ; This work was supported by grants from NIH ⁄ NIA R01 AG 17922, the Natural Science Foundation of China (30520120072 and 30670669), National Basic Research Program (2006CB500804), the Foundation of Chinese Academy of Sciences (KSCX2-SW-217), 973 Program (2007CB947703)
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5467
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室中国科学院昆明灵长类研究中心
通讯作者	audie.leventhal@m.cc.utah.edu; yuanma0716@vip.sina.com
作者单位	1.Section of Primate Neuroscience Research, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming, Yunnan, China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Graduate School of Chinese Academy of Sciences, Beijing, China 4.Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei, Anhui, China 5.Department of Neurobiology and Anatomy, School of Life Science, University of Utah, Salt Lake City, UT 84132, USA 6.Section of Primate Neuroscience Research, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Kunming, Yunnan, China 7.Kunming Primate Center, Chinese Academy of Sciences, Kunming, Yunnan, China 8.Graduate School of Chinese Academy of Sciences, Beijing, China 9.Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei, Anhui, China 10.Department of Neurobiology and Anatomy, School of Life Science, University of Utah, Salt Lake City, UT 84132, USA
推荐引用方式 GB/T 7714	Zhang J,Wang XS,Wang YC,et al. Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2008,28(1):201-207.
APA	Zhang J.,Wang XS.,Wang YC.,Fu Y.,Liang Z.,...&yuanma0716@vip.sina.com.(2008).Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys.EUROPEAN JOURNAL OF NEUROSCIENCE,28(1),201-207.
MLA	Zhang J,et al."Spatial and temporal sensitivity degradation of primary visual cortical cells in senescent rhesus monkeys".EUROPEAN JOURNAL OF NEUROSCIENCE 28.1(2008):201-207.

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