Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice

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	Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice
	Fu Y 1,2,3; Wang CK 4; Wang JH 1,2; Lei YL 1,2; Ma YY*1,2; yuanma0716@vip.sina.com
	2008
发表期刊	CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
ISSN	0305-1870
卷号	35 期号:7 页码:797-800
摘要	1. In the present study, we investigated the short- and long-term effects of extremely low-frequency (ELF) magnetic fields on spatial recognition memory in mice by using a two-trial recognition Y-maze that is based on the innate tendency of rodents to explore novel environments. 2. Mice were exposed to 25 or 50 Hz electromagnetic fields for either 7 (short term) or 25 days (long term) and then tested in the Y-maze. 3. The results indicated that neither short- nor long-term exposure to magnetic fields affected the locomotor activity of mice in the Y-maze. However, long-term exposure to 50 Hz fields reduced recognition of the novel arm. 4. Our findings suggest that ELF magnetic fields impair spatial recognition memory in the Y-maze depending on the field strength and/or duration of exposure.
关键词	Electromagnetic Field Extremely Low-frequency Mice Spatial Recognition Memory Y-maze
学科领域	Pharmacology & Pharmacy ; Physiology
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2).
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收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2). ; This study was supported by National Science Foundation of China (NSFC 30470553, 30530270, 30670669 and 30770700), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810, 2006AA02A116), the Major State Basic Research of China (NO2003CB716600), Chinese–Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33, YZ200737), National Key Technologies R&D Program and Yunnan Science and Technique Program (2006PT08-2).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5469
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室科研部门_神经系统编码（胡新天）中国科学院昆明灵长类研究中心
通讯作者	yuanma0716@vip.sina.com
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology 2.Kunming Primate Research Center, Chinese Academy of Sciences, Kunming, Yunnan 3.Graduate University of Chinese Academy of Sciences, Beijin 4.Department of Pharmacology, Medical College, Xiamen University, Xiamen, Fujian, China
推荐引用方式 GB/T 7714	Fu Y,Wang CK,Wang JH,et al. Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(7):797-800.
APA	Fu Y,Wang CK,Wang JH,Lei YL,Ma YY*,&yuanma0716@vip.sina.com.(2008).Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,35(7),797-800.
MLA	Fu Y,et al."Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 35.7(2008):797-800.

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