Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use

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	Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use
	Gu CL 1; Li P 2; Hu B 1; Ouyang XP 1; Fu J 1; Gao J 1; Song Z 1; Han L 1; Ma YY 3; Tian SW1; Hu XT3; tsw.neuro@126.com ; xhu@mail.kiz.ac.cn
	2008
发表期刊	NEUROPSYCHOPHARMACOLOGY
ISSN	0893-133X
卷号	33 期号:3 页码:666-673
合作性质	其它
摘要	Previous studies have shown that opioid transmission plays an important role in learning and memory. However, little is known about the course of opiate-associated learning and memory deficits after cessation of chronic opiate use in a behavioral animal model. In the present study, we examined the effects of chronic morphine on fear extinction, an important preclinical model for behavior therapy of human anxiety disorders. Rats were administrated subcutaneously morphine hydrochloride or saline twice per day for continuous 10 days. Rats received a cued or contextual fear conditioning session 7 days after the last morphine injection. During subsequent days, rats received four cued or contextual extinction sessions ( one session per day). Percent freezing was assessed during all phases of training. Chronic morphine did not affect the acquisition of cued fear response or the initial encoding of extinction memory within each session, but produced an impairment in the between-session extinction. However, the same morphine treatment schedule did not affect the acquisition or extinction of contextual fear response. These results suggest that the effects of chronic morphine on memory for fear extinction are complex. Chronic morphine selectively impairs extinction of cued fear response. This deficit in fear extinction may be one of those critical components that contribute to the high prevalence of anxiety disorders in opiate addicts.
关键词	Anxiety Disorders Amygdala Rats Prefrontal Cortex Chronic Morphine Fear Extinction
资助者	This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01).
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收录类别	SCI
语种	英语
资助者	This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01). ; This study was supported by A Project Supported by Scientific Research Fund of Hunan Provincial Education Department (05B045), National Basic Research Program of China (2002CB410803-04), Nanhua University Doctor Foun- dation (5-03-XJQ-03-041), Chinese Academy of Sciences Grants (KSCX2-SW), National Basic Research Program of China, Chinese Science Foundation (30470553), and Program of Chinese Academy of Sciences (KJCX1-01).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5481
专题	认知障碍病理学科研部门_神经系统编码（胡新天）
通讯作者	tsw.neuro@126.com; xhu@mail.kiz.ac.cn
作者单位	1.Department of Physiology, College of Medicine, Nanhua University, Hengyang, Hunan, PR China 2.Department of Biology, College of Life Science and Technology, Nanhua University, Hengyang, Hunan, PR China 3.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China
推荐引用方式 GB/T 7714	Gu CL,Li P,Hu B,et al. Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(3):666-673.
APA	Gu CL.,Li P.,Hu B.,Ouyang XP.,Fu J.,...&xhu@mail.kiz.ac.cn.(2008).Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use.NEUROPSYCHOPHARMACOLOGY,33(3),666-673.
MLA	Gu CL,et al."Chronic morphine selectively impairs cued fear extinction in rats: Implications for anxiety disorders associated with opiate use".NEUROPSYCHOPHARMACOLOGY 33.3(2008):666-673.

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