Aging Affects the Neural Representation of Speed in Macaque Area MT

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	Aging Affects the Neural Representation of Speed in Macaque Area MT
	Yang Y 1; Zhang J 2; Liang Z 1; Li GX 1; Wang YC 1,3; Ma YY 2; Zhou YF*1,4; Leventhal AG 1,3; zhouy@ustc.edu.cn
	2009
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	19 期号:9 页码:1957-1967
合作性质	其它
摘要	Human perception of speed declines with age. Much of the decline is probably mediated by changes in the middle temporal (MT) area, an extrastriate area whose neural activity is linked to the perception of speed. In the present study, we used random-dot patterns to study the effects of aging on speed-tuning curves in cortical area MT of macaque visual cortex. Our results provide evidence for a significant degradation of speed selectivity in MT. Cells in old animals preferred lower speeds than did those in young animals. Response modulation and discriminative capacity for speed in old monkeys were also significantly weaker than those in young ones. Concurrently, MT cells in old monkeys showed increased baseline responses, peak responses and response variability, and these changes were accompanied by decreased signal-to-noise ratios. We also found that speed discrimination thresholds in old animals were higher than in young ones. The foregoing neural changes may mediate the declines in visual motion perception that occur during senescence.
关键词	Aging Area Mt Degradation Inhibition Macaque Speed
学科领域	Neurosciences
资助者	National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L.
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收录类别	SCI
语种	英语
资助者	National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L. ; National Basic Research Program of China (2009CB941303 and 2005CB522803); Natural Science Foundation of China (30520120072), to Y. Z.; and the National Institute of Health (R01 AG 17922) to A. G. L.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5493
专题	认知障碍病理学
通讯作者	zhouy@ustc.edu.cn
作者单位	1.Vision Research Laboratory, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China 2.Laboratory of Primate Cognitive Neuroscience, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China 3.Department of Neurobiology and Anatomy, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA 4.State key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China
推荐引用方式 GB/T 7714	Yang Y,Zhang J,Liang Z,et al. Aging Affects the Neural Representation of Speed in Macaque Area MT[J]. CEREBRAL CORTEX,2009,19(9):1957-1967.
APA	Yang Y.,Zhang J.,Liang Z.,Li GX.,Wang YC.,...&zhouy@ustc.edu.cn.(2009).Aging Affects the Neural Representation of Speed in Macaque Area MT.CEREBRAL CORTEX,19(9),1957-1967.
MLA	Yang Y,et al."Aging Affects the Neural Representation of Speed in Macaque Area MT".CEREBRAL CORTEX 19.9(2009):1957-1967.

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