Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference

KIZ OpenIR > 认知障碍病理学

	Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference
	Zhang J 1,3; Tan H 4; Niu HC 1,2; Wang JH 1,3; Tang XD 5; Sanford LD 5; Ma YY*1,2; yuanma0716@vip.sina.com
	2009
发表期刊	ADDICTION BIOLOGY
ISSN	1355-6215
卷号	14 期号:2 页码:174-184
合作性质	其它
摘要	Learning and memory play an important role in morphine addiction. Status epilepticus (SE) can impair the spatial and emotional learning and memory. However, little is known about the effects of SE on morphine-induced conditioned place preference (CPP). The present study was designed to investigate the effects of SE on morphine CPP, with food CPP being used as a control. The effects of SE on spatial memory in the Morris water maze (MWM) and Y-maze were investigated. SE was induced in adult mice using intraperitoneal injection of pentylenetetrazole; control mice received saline. The data indicated that SE had no effects on the formation of morphine CPP; however, the formation of food CPP was blocked by SE. Meanwhile, spatial memory assayed in the MWM and Y-maze was impaired by SE. In addition, the data demonstrated that SE did not cause a lasting disturbance of motor activity nor a change in the mice's appetite. These results suggested that although SE had no effects on morphine CPP, there was impaired food CPP and spatial memory in both the MWM and the Y-maze. The mechanisms underlying memory process of morphine CPP may be different from other types of memory.
关键词	Conditioned Place Preference Learning And Memory Morphine Morris Water Maze Status Epilepticus Y-maze
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program.
收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program. ; This study was supported by National Science Foundation of China (NSFC 30470553, 30770700 and 30530270), 973 program (2005CB522803, 2007CB947703), 863 program (O7013810), Chinese- Finnish International Collaboration Project-neuro (30621130076), Program of CASC (KSCX1-YW-R-33) and National Key Technologies R&D Program.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5495
专题	认知障碍病理学科研部门_神经系统编码（胡新天）中国科学院昆明灵长类研究中心
通讯作者	yuanma0716@vip.sina.com
作者单位	1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming,Yunnan, China 2.Kunming Primate Center, Chinese Academy of Sciences, Kunming,Yunnan, China 3.Graduate School of Chinese Academy of Sciences,Beijing,China 4.College of Mechanical and Electrical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing,Jiangsu,China 5.Department of Pathology and Anatomy, EasternVirginia Medical School, USA
推荐引用方式 GB/T 7714	Zhang J,Tan H,Niu HC,et al. Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference[J]. ADDICTION BIOLOGY,2009,14(2):174-184.
APA	Zhang J.,Tan H.,Niu HC.,Wang JH.,Tang XD.,...&yuanma0716@vip.sina.com.(2009).Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference.ADDICTION BIOLOGY,14(2),174-184.
MLA	Zhang J,et al."Pentylenetetrazole-induced status epilepticus following training does not impair expression of morphine-induced conditioned place preference".ADDICTION BIOLOGY 14.2(2009):174-184.

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