Detour behavior changes associated with prenatal morphine exposure in 11-day-old chicks

KIZ OpenIR > 认知障碍病理学

	Detour behavior changes associated with prenatal morphine exposure in 11-day-old chicks
	Sun HY 1; Che Y 2; Liu XF 3; Ma YY*1,4; yuanma0716@vip.sina.com
	2010
发表期刊	INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN	0736-5748
卷号	28 期号:3 页码:239-243
合作性质	其它
摘要	The central nervous system exhibits remarkable plasticity in early life. Prenatal morphine exposure may induce adverse behavioral effects on the neonate and the developing offspring. In the present study, we investigated the effect of prenatal morphine exposure (daily from embryonic days 12-16, 20 mg/kg) on 11-day-old chicks using two forms of spatial paradigms: one trial detour behavior task in which animals must bypass an obstacle to reach the desired goal without any training and detour learning task which required several trials of training to reach the detour criterion. The results showed that, on the condition that chicks could successfully detour in the first trial, morphine exposed chicks exhibited longer detour latency to finish the task, coupled by a preference for turning right versus turning left. In contrast, no significant difference in learning and memory was found in detour learning task between morphine exposed chicks and saline chicks. These findings suggest specific behavioral changes associated with prenatal exposure to opioids during mid to late gestation, also raise attention to the possible health hazard from pregnancy drug use in everyday life. (C) 2010 ISDN.
关键词	Detour Behavior Chicks Morphine Prenatal Exposure
资助者	This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825).
收录类别	SCI
语种	英语
资助者	This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825). ; This study was supported by National Science Foundation of China (NSFC 30770700 and 30870825).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5501
专题	认知障碍病理学
通讯作者	yuanma0716@vip.sina.com
作者单位	1.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, PR China 2.School of Life Science, Suzhou University, Suzhou, Jiangsu, 215006, PR China 3.Department of Physiology, BengbuMedical College, Bengbu, Anhui, 233030, PR China 4.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, PR China
推荐引用方式 GB/T 7714	Sun HY,Che Y,Liu XF,et al. Detour behavior changes associated with prenatal morphine exposure in 11-day-old chicks[J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2010,28(3):239-243.
APA	Sun HY,Che Y,Liu XF,Ma YY*,&yuanma0716@vip.sina.com.(2010).Detour behavior changes associated with prenatal morphine exposure in 11-day-old chicks.INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,28(3),239-243.
MLA	Sun HY,et al."Detour behavior changes associated with prenatal morphine exposure in 11-day-old chicks".INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 28.3(2010):239-243.

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