Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice

	Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice
	Ingram N 1,2; Martin S 1; Wang JH 1,3; van der Laan S 1; Loiacono R 2; van den Buuse M*1,4; mvandenbuuse@mhri.edu.au
	2005
发表期刊	NEUROPHARMACOLOGY
ISSN	0028-3908
卷号	48 期号:1 页码:80-92
合作性质	其它
摘要	The aim of the present Study was to investigate if different levels of circulating corticosterone (CORT) modulate the effect of nicotine on prepulse inhibition (PPI), a measure of sensorimotor gating that is disrupted in schizophrenia and other mental illnesses. Four groups of mice were investigated: sham-operated, adrenalectomized (ADX) and implanted with a cholesterol pellet, ADX and implanted with a 10 mg CORT pellet, or ADX and 50 mg, of CORT. Different CORT levels or doses of nicotine did not significantly affect startle responses. Baseline PPI was significantly reduced in mice implanted with the highest dose of CORT. In ADX mice implanted with cholesterol, nicotine treatment influenced PPI depending on the prepulse intensity. In ADX mice implanted with 50 mg of CORT, treatment with 10 mg/kg of nicotine caused a significant increase in PPI at all prepulse intensities. Binding studies showed that corticosterone treatment had significantly affected nicotinic acetylcholine receptor (nAChR) density in the mouse brain. Treatment with 50 mg CORT decreased I-125-epibatidine binding in the globus pallidus and I-125-alpha-bungarotoxin binding in the claustrum. These results suggest a possible interaction of corticosterone and nicotine at the level of the alpha4- and alpha7-type nAChR in the regulation of PPI. In situations of high circulating levels of corticosterone, nicotine may be beneficial to restore disruption of PPI.
关键词	Prepulse Inhibition Nicotine Stress Adrenal Corticosterone Schizophrenia
资助者	Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia.
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收录类别	SCI
语种	英语
资助者	Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia. ; Parts of the study were supported by the National Health and Medical Research Council of Australia.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5513
专题	科研部门_神经系统编码（胡新天）
通讯作者	mvandenbuuse@mhri.edu.au
作者单位	1.Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia 2.Department of Pharmacology, Monash University, Clayton, Melbourne, Australia 3.Section of Cognitive Brain Research, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650233, PR. China 4.Department of Pharmacology, University of Melbourne, Melbourne, Australia
推荐引用方式 GB/T 7714	Ingram N,Martin S,Wang JH,et al. Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice[J]. NEUROPHARMACOLOGY,2005,48(1):80-92.
APA	Ingram N.,Martin S.,Wang JH.,van der Laan S.,Loiacono R.,...&mvandenbuuse@mhri.edu.au.(2005).Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice.NEUROPHARMACOLOGY,48(1),80-92.
MLA	Ingram N,et al."Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice".NEUROPHARMACOLOGY 48.1(2005):80-92.

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