| Comparative analysis of CpG islands in four fish genomes | |
| Han L1,2,3; Zhao ZM*1,4,5; zzhao@vcu.edu | |
| 2008 | |
| 发表期刊 | COMPARATIVE AND FUNCTIONAL GENOMICS
 |
| ISSN | 1531-6912 |
| 期号 | X页码:e565631 |
| 合作性质 | 其它 |
| 摘要 | There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are considered gene markers and involved in gene regulation. To date, there has been no genome-wide analysis of CGIs in the fish genome. We first evaluated the performance of three popular CGI identification algorithms in four fish genomes (tetraodon, stickleback, medaka, and zebrafish). Our results suggest that Takai and Jones' (2002) algorithm is most suitable for comparative analysis of CGIs in the fish genome. Then, we performed a systematic analysis of CGIs in the four fish genomes using Takai and Jones' algorithm, compared to other vertebrate genomes. We found that both the number of CGIs and the CGI density vary greatly among these genomes. Remarkably, each fish genome presents a distinct distribution of CGI density with some genomic factors (e. g., chromosome size and chromosome GC content). These findings are helpful for understanding evolution of fish genomes and the features of fish CGIs. |
| 资助者 | This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. ; This project was supported by the Thomas F. and Kate Miller Jeffress Memorial Trust Fund and a NARSAD Young Investigator Award to Z. Zhao. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/5519 |
| 专题 | 科研部门_比较基因组学（宿兵） 遗传资源与进化国家重点实验室 |
| 通讯作者 | zzhao@vcu.edu |
| 作者单位 | 1.Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Graduate School, Chinese Academy of Sciences, Beijing 100039, China 4.Department of Human Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA 5.Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA 23284, USA |
| 推荐引用方式 GB/T 7714 | Han L,Zhao ZM*,zzhao@vcu.edu. Comparative analysis of CpG islands in four fish genomes[J]. COMPARATIVE AND FUNCTIONAL GENOMICS,2008(X):e565631. |
| APA | Han L,Zhao ZM*,&zzhao@vcu.edu.(2008).Comparative analysis of CpG islands in four fish genomes.COMPARATIVE AND FUNCTIONAL GENOMICS(X),e565631. |
| MLA | Han L,et al."Comparative analysis of CpG islands in four fish genomes".COMPARATIVE AND FUNCTIONAL GENOMICS .X(2008):e565631. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2008565631.pdf（635KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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