Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction

KIZ OpenIR > 生殖与发育生物学

	Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction
	Li XL; Su L*; suleil@hotmail.com
	2004
发表期刊	VETERINARY RESEARCH COMMUNICATIONS
ISSN	0165-7380
卷号	28 期号:8 页码:719-725
合作性质	其它
摘要	Large intestinal obstruction (LIO) in farm animals can cause a ischaemic necrosis of intestinal tissue, eventually leading to death. The roles of endothelin-1 (ET-1) and nitric oxide (NO) are not well understood in the process of LIO, but evidence suggests that endothelial-derived mediators may participate. In the present study, ET-1 concentration and total nitric oxide synthase (NOS) activity were measured in heart, liver, pancreas, lung and kidney in a model of LIO in sheep. Our data demonstrated that ET-1 concentration and NOS activity were altered, with significant increases of ET-1 in heart, lung and kidney and of NOS activity in pancreas and kidney, but a marked decline of NOS activity in liver (p<0.05). It is postulated that these alterations in NOS activity and ET-1 concentration may contribute to the progressive loss of organ function, and finally lead to death in LIO in sheep.
关键词	Endothelin-1 Large Intestinal Obstruction Nitric Oxide Synthase
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5567
专题	生殖与发育生物学
通讯作者	suleil@hotmail.com
作者单位	Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li XL,Su L*,suleil@hotmail.com. Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction[J]. VETERINARY RESEARCH COMMUNICATIONS,2004,28(8):719-725.
APA	Li XL,Su L*,&suleil@hotmail.com.(2004).Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction.VETERINARY RESEARCH COMMUNICATIONS,28(8),719-725.
MLA	Li XL,et al."Changes of tissue endothelin-1 and nitric oxide synthase in a sheep model of large intestinal obstruction".VETERINARY RESEARCH COMMUNICATIONS 28.8(2004):719-725.

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