Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection

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	Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection
	Li CH 1,2,3; Fu YS 4; Lu L1; Ji WZ 2; Yu J 5; Hagedorn CH 1; Zhang LQ5,6; llu@kumc.edu ; lzhang@adarc.org
	2006
发表期刊	JOURNAL OF MEDICAL VIROLOGY
ISSN	0146-6615
卷号	78 期号:8 页码:1061-1069
合作性质	其它
摘要	In one of our recent studies, two HCV genotype 6 variants were identified in patients from Hong Kong and Guangxi in southern China, with injection drug use and HIV-1 co-infection. We report the complete genomic sequences for these two variants: GX004 and HK6554. Their entire genome lengths were 9,468 and 9,462 nt; the 5' UTRs were 338 nt followed by single ORFs of 9,069 nt; the 3' UTRs were 61 and 55 nt including 29 and 23 nt poly(U) tracks. Phylogenetic analysis using a maximum likelihood method showed that HK6554 was classified into subtype 6g and GX004 represented the first complete genome sequence for subtype 6e. Further analysis with reference sequences in three different genomic regions revealed that GX004 closely clustered with a group of subtype 6e variants, which were previously exclusively found in Vietnam and recently increasingly identified in injection drug users from the Guangxi province in southern China that borders Vietnam. This suggests that subtype 6e could become epidemic in southern China by network transmission among injection drug users.
关键词	Hcv Genotype Sequence Injection Drug Use
资助者	Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04.
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收录类别	SCI
语种	英语
资助者	Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04. ; Grant sponsor: NIH; Grant numbers: CA-063064, 5 P20 RR016443-04.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5597
专题	生殖与发育生物学
通讯作者	llu@kumc.edu; lzhang@adarc.org
作者单位	1.Division of Gastroenterology/Hepatology, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 3.Graduate School of the Chinese Academy of Sciences, Beijing, China 4.Guangzhou Blood Center, Guangzhou City, Guangdong Province, China 5.The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 6.AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
推荐引用方式 GB/T 7714	Li CH,Fu YS,Lu L*,et al. Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection[J]. JOURNAL OF MEDICAL VIROLOGY,2006,78(8):1061-1069.
APA	Li CH.,Fu YS.,Lu L*.,Ji WZ.,Yu J.,...&lzhang@adarc.org.(2006).Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection.JOURNAL OF MEDICAL VIROLOGY,78(8),1061-1069.
MLA	Li CH,et al."Complete genomic sequences for hepatitis C virus subtypes 6e and 6g isolated from Chinese patients with injection drug use and HIV-1 co-infection".JOURNAL OF MEDICAL VIROLOGY 78.8(2006):1061-1069.

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