Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression

KIZ OpenIR > 生殖与发育生物学

	Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression
	Ren GW 1; Su JJ 1,2; Zhang LY 1; Zhao X 1; Ling WF 1; L'Huillie A 1; Zhang JM 1; Lu YQ 2,3; Roberts AI 1; Ji WZ 3; Zhang HT 3; Rabson AB 1,4; Shi YF*1,2,3; shiyu@umdnj.edu
	2009
发表期刊	STEM CELLS
ISSN	1066-5099
卷号	27 期号:8 页码:1954-1962
合作性质	其它
摘要	Bone marrow-derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we show here, the mechanism of MSC-mediated immunosuppression varies among different species. Immunosuppression by human-or monkey-derived MSCs is mediated by indoleamine 2,3-dioxygenase (IDO), whereas mouse MSCs utilize nitric oxide, under the same culture conditions. When the expression of IDO and inducible nitric oxide synthase (iNOS) were examined in human and mouse MSCs after stimulation with their respective inflammatory cytokines, we found that human MSCs expressed extremely high levels of IDO, and very low levels of iNOS, whereas mouse MSCs expressed abundant iNOS and very little IDO. Immunosuppression by human MSCs was not intrinsic, but was induced by inflammatory cytokines and was chemokine-dependent, as it is in mouse. These findings provide critical information about the immunosuppression of MSCs and for better application of MSCs in treating immune disorders.
关键词	Mesenchymal Stem Cells Immunosuppression Nitric Oxide Indoleamine 2 Chemokine 3-dioxygenase
资助者	This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58.
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收录类别	SCI
语种	英语
资助者	This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58. ; This work was supported by grants from New Jersey Commis- sion on Science and Technology (NJCST-2042-014-84), Chi- nese Academy of Sciences, National Institutes of Health (AI057596 and AI50222), and the National Space Biomedical Research Institute (IIH00405) supported by the National Aero- nautics and Space Administration through Cooperative Agree- ment NCC 9-58.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5641
专题	生殖与发育生物学分子免疫生物学中国科学院昆明灵长类研究中心
通讯作者	shiyu@umdnj.edu
作者单位	1.Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School- University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA 2.Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 4.Child Health Institute of New Jersey, Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
推荐引用方式 GB/T 7714	Ren GW,Su JJ,Zhang LY,et al. Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression[J]. STEM CELLS,2009,27(8):1954-1962.
APA	Ren GW.,Su JJ.,Zhang LY.,Zhao X.,Ling WF.,...&shiyu@umdnj.edu.(2009).Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression.STEM CELLS,27(8),1954-1962.
MLA	Ren GW,et al."Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression".STEM CELLS 27.8(2009):1954-1962.

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