Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo

	Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo
	Dong ZF 1,2,3; Zhong WX 4; Tian M 1,2,3; Han HL 1,2,3; Cao J 1,2,3; Xu TL 5; Luo JH4; Xu L1,2,3,6; luojianhong@zju.edu.cn ; lxu@vip.163.com
	2006
发表期刊	HIPPOCAMPUS
ISSN	1050-9631
卷号	16 期号:12 页码:1017-1025
产权排序	The National Natural Science Foundation of China; Grant numbers: 30530250 and 30470549; Grant sponsor: The Ministry of Sci- ence and Technology; Grant numbers: 2006CB500800.
合作性质	其它
摘要	Stress impairs hippocampal long-term potentiation (LTP), but it is unknown whether the stress evoked by opiate withdrawal has the same effect. Here the authors report that opiate withdrawal for 4 days does not influence basal synaptic transmission, but results in a greatly increased LTP in hippocampal CA1 area in anesthetized rats. Elevated-platform stress enabled a large LTP in rats withdrawn for only 18 h, but the glucocorticoid receptor antagonist RU38486 (twice per day for 3 days) prevented the large LTP on 4 days withdrawal. Moreover, 4 days withdrawal enhanced the NMDAR-mediated EPSCs, in which the NR2A-containing NMDAR-mediated EPSC was increased but the NR2B-containing NMDAR-mediated EPSC was decreased. These results suggest that adaptive changes of the NMDAR and glucocorticoid receptor functions during 4 days of opiate withdrawal may enable stress to facilitate hippocampal LTP, potentially contributing to the opiate withdrawal experience-dependent modifications of hippocampal functions.
关键词	Opiate Withdrawal Long-term Potentiation Hippocampal Ca1 Stress
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收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5877
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	luojianhong@zju.edu.cn; lxu@vip.163.com
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kun- ming, People’s Republic of China 2.Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kun- ming, People’s Republic of China 3.Graduate School of the Chinese Acad- emy of Sciences, Beijing, People’s Republic of China 4.Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China 5.Institute of Neuroscience, Shanghai Institutes for Bio- logical Sciences, the Chinese Academy of Sciences, Shanghai, People’s Republic of China 6.Mental Health Institute, the 2nd Xiangya Hospital of Central South University, Changsha, People’s Republic of China
推荐引用方式 GB/T 7714	Dong ZF,Zhong WX,Tian M,et al. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo[J]. HIPPOCAMPUS,2006,16(12):1017-1025.
APA	Dong ZF.,Zhong WX.,Tian M.,Han HL.,Cao J.,...&lxu@vip.163.com.(2006).Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo.HIPPOCAMPUS,16(12),1017-1025.
MLA	Dong ZF,et al."Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo".HIPPOCAMPUS 16.12(2006):1017-1025.

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