Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats

	Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats
	Zhang LH 1,2; Xu L 3; Xu TL*1,2; tlxu@ion.ac.cn, xutianle@ustc.edu.cn
	2006
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN	0006-291X
卷号	344 期号:3 页码:721-726
合作性质	其它
摘要	Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their roles in synaptic transmission are unclear. In this study, we examined the effect of GlyR activation on paired-pulse stimulation of the whole-cell postsynaptic currents (PSCs) in the Schaffer-CA1 synapses in rat hippocampal slices. Bath application of glycine reduced the amplitude of PSCs, accompanied by all increase ill holding current and resting conductance. Moreover, glycine application increased the paired-pulse ratio (PPR) of PSCs significantly, all effect largely abolished by the GlyR specific antagonist strychnine. Interestingly, glycine application had no significant effect oil either the amplitude or the PPR of excitatory postsynaptic currents (EPSCs). Our findings suggest that GlyR activation regulates hippocampal short-term plasticity by altering GABAergic neurotransmission.
关键词	Glycine Receptor Gaba(a) Receptor Hippocampus Brain Slice Synaptic Transmission Short-term Plasticity Paired-pulse Depression Paired-pulse Facilitation
资助者	This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu.
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收录类别	SCI
语种	中文
资助者	This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu. ; This study was supported by the National Basic Re- search Program of China (No. 2006CB500803) and the National Natural Science Foundation of China (Nos. 30125015 and 30321002) to T.-L. Xu.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5893
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	tlxu@ion.ac.cn, xutianle@ustc.edu.cn
作者单位	1.School of Life Sciences, University of Science and Technology of China, Hefei 230027, China 2.Institute of Neuroscience and Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Zhang LH,Xu L,Xu TL*,et al. Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,344(3):721-726.
APA	Zhang LH,Xu L,Xu TL*,&tlxu@ion.ac.cn, xutianle@ustc.edu.cn.(2006).Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,344(3),721-726.
MLA	Zhang LH,et al."Glycine receptor activation regulates short-term plasticity in CA1 area of hippocampal slices of rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 344.3(2006):721-726.

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