Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study

	Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study
	Li LJ1; Ma N 1; Li ZX 1; Tan LW 1; Liu J 2; Gong GL 3; Shu N 3; He Z 2; Jiang TZ3; Xu L 4; llj2920@163.com ; jiangtz@nlpr.ia.ac.cn
	2007
发表期刊	BRAIN RESEARCH
ISSN	0006-8993
卷号	1168 期号:X 页码:124-128
合作性质	其它
摘要	Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DTI). However, it is still unclear whether the same changes exist in younger patients. In the present study, we first utilized DTI to detect prefrontal white matter in young adults with MDD. Nineteen first-episode, untreated young adults with MDD and twenty age- and gender-matched healthy controls were recruited. DTI and localizing anatomic data were acquired. Then, the regions of interest (ROIs) were located in prefrontal white matter at 4 mm inferior, and 0, 4, 8,12,16 and 20 mm superior to the anterior commissure-posterior commissure (AC-PC) plane, respectively. Compared with healthy controls, patients with MDD showed significantly lower fractional anisotropy (FA) values in prefrontal white matter at bilateral 20 mm, right 16 mm and right 12 mm above the AC-PC. Furthermore, there was no significant correlation between the FA value of any ROI and illness course as well as severity of depression. Together with previous findings, the present results suggest that microstructural abnormalities in prefrontal white matter may occur early in the course of MDD and may be related to the neuropathology of depression throughout adulthood from young to elderly.
关键词	Major Depressive Disorder Dti White Matter Fractional Anisotropy Young Adult
资助者	This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China.
URL	查看原文
收录类别	SCI
语种	英语
资助者	This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China. ; This work was supported by research grants from National Natural Science Foundation (30670751 and 30470621 to L.J.L., 30570509 and 30425004 to T.Z.J.) National Science and Tech- nology Program (2007BAI17B02 to L.J.L. and N.M.) and National 973 Program (2006CB500800 to L.J.L. and L.X.) of China.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5903
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	llj2920@163.com; jiangtz@nlpr.ia.ac.cn
作者单位	1.Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China 2.Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China 3.National Laboratory of Pattern Recognition, Automation Institute, Chinese Academy of Sciences, Beijing, China 4.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Li LJ*,Ma N,Li ZX,et al. Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study[J]. BRAIN RESEARCH,2007,1168(X):124-128.
APA	Li LJ*.,Ma N.,Li ZX.,Tan LW.,Liu J.,...&jiangtz@nlpr.ia.ac.cn.(2007).Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study.BRAIN RESEARCH,1168(X),124-128.
MLA	Li LJ*,et al."Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study".BRAIN RESEARCH 1168.X(2007):124-128.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
20071168124.pdf（341KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文