Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress

	Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress
	Yang JL 1,2; Hou CL 1; Ma N 1; Liu J 1; Yang Y 1; Zhou JS 1; Xu L1,3; Li LJ1; lxu@vip.163.com ; lilj9016@public.cs.hn.cn
	2007
发表期刊	NEUROBIOLOGY OF LEARNING AND MEMORY
ISSN	1074-7427
卷号	87 期号:2 页码:257-263
合作性质	其它
摘要	Prenatal stress can cause long-term effects on cognitive functions in offspring. Hippocampal synaptic plasticity, believed to be the mechanism underlying certain types of learning and memory, and known to be sensitive to behavioral stress, can be changed by prenatal stress. Whether enriched environment treatment (EE) in early postnatal periods can cause a recovery from these deficits is unknown. Experimental animals were Wistar rats. Prenatal stress was evoked by 10 foot shocks (0.8 mA for 1 s, 2-3 min apart) in 30 min per day at gestational day 13-19. After weaning at postnatal day 22, experimental offspring were given the enriched environment treatment through all experiments until tested (older than 52 days age). Electrophysiological and Morris water maze testing was performed at 8 weeks of age. The results showed that prenatal stress impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in the hippocampal CA1 region in the slices. Furthermore, prenatal stress exacerbated the effects of acute stress on hippocampal LTP and LTD, and also impaired spatial learning and memory in the Morris water maze. However, all these deficits induced by prenatal stress were recovered by enriched environment treatment. This work observes a phenomenon that may contribute to the understanding of clinically important interactions among cognitive deficit, prenatal stress and enriched environment treatment. Enriched environment treatment on early postnatal periods may be one potentially important target for therapeutic interventions in preventing the prenatal stress-induced cognitive disorders.
关键词	Long-term Potentiation Long-term Depression Learning And Memory Prenatal Stress Enriched Environment Treatment
资助者	This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.).
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收录类别	SCI
语种	英语
资助者	This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.). ; This work was supported by grants from National Sci- ence Foundation of China (30170342 and 30470621 to L.J.L. and 30530250 and 30470549 to L.X.), and Basic Research 973 Program (2006CB500800 to L. X., L.J.L. and J.C.).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5909
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	lxu@vip.163.com; lilj9016@public.cs.hn.cn
作者单位	1.Mental Health Institute, The 2nd Xiangya Hospital, Central South University, Changsha 410011, PR China 2.Tianjin Anding Hospital, Tianjin 300074, PR China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, PR China
推荐引用方式 GB/T 7714	Yang JL,Hou CL,Ma N,et al. Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2007,87(2):257-263.
APA	Yang JL.,Hou CL.,Ma N.,Liu J.,Yang Y.,...&lilj9016@public.cs.hn.cn.(2007).Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress.NEUROBIOLOGY OF LEARNING AND MEMORY,87(2),257-263.
MLA	Yang JL,et al."Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress".NEUROBIOLOGY OF LEARNING AND MEMORY 87.2(2007):257-263.

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