Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition

	Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition
	Zhang LH 1,2; Gong N 1,2; Fei D 1; Xu L 3; Xu TL*1; tlxu@ion.ac.cn
	2008
发表期刊	NEUROPSYCHOPHARMACOLOGY
ISSN	0893-133X
卷号	33 期号:3 页码:701-711
合作性质	其它
摘要	Functional glycine receptors (GlyRs) are enriched in the hippocampus, but their role in hippocampal function remains unclear. Since the concentration of ambient glycine is determined by the presence of powerful glycine transporter (GlyT), we blocked the reuptake of glycine in hippocampal slices to examine the role of GlyRs. Antagonists of GlyT type 1 (GlyT1) but not that of GlyT type 2 (GlyT2) induced excitatory postsynaptic potential (EPSP)-spike depression, which was reversed by the specific GlyR antagonist strychnine. Moreover, endogenously elevating the glycine concentration with the GlyT1 antagonists facilitated NMDA receptor-dependent longterm potentiation induction, and elicited a strychnine-sensitive chloride current. In addition, impairment of glial function with fluoroacetate blocked the effect of GlyT1 antagonists on the EPSP-spike curve. Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. These results indicate an essential role of GlyTs in fine-tuning tonic activation of GlyRs and suggest a potential role of GlyR-dependent EPSP-spike depression in hippocampal network stability.
关键词	Glycine Receptor Glycine Transporter Hippocampus Epsp-spike Coupling Tonic Inhibition Glia
资助者	This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35).
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收录类别	SCI
语种	英语
资助者	This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35). ; This study was supported by the National Natural Science Foundation of China (No. 30621062), the National Basic Research Program of China (No. 2006CB500803) and the Knowledge Innovation Project from the Chinese Academy of Sciences (KSCX2-YW-R-35).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5923
专题	科研部门_学习记忆的分子神经机制（徐林）
通讯作者	tlxu@ion.ac.cn
作者单位	1.Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China 2.School of Life Sciences, University of Science and Technology of China, Hefei, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Zhang LH,Gong N,Fei D,et al. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition[J]. NEUROPSYCHOPHARMACOLOGY,2008,33(3):701-711.
APA	Zhang LH,Gong N,Fei D,Xu L,Xu TL*,&tlxu@ion.ac.cn.(2008).Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.NEUROPSYCHOPHARMACOLOGY,33(3),701-711.
MLA	Zhang LH,et al."Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition".NEUROPSYCHOPHARMACOLOGY 33.3(2008):701-711.

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