Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex

	Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex
	Hao YH 1; Yan Q 2; Liu HH 1; Xu L 1,3; Xue ZM 1; Song XQ 4; Kaneko Y 5; Jiang TZ 6; Liu ZN1; Shan BC2; zningl@163.com ; shanbc@mail.ihep.ac.cn
	2009
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	114 期号:37624 页码:18-135
合作性质	其它
摘要	Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophrenia. However, it remains unclear whether schizophrenia patients and their healthy siblings share a specific pattern of disruption of WM integrity that may be related to the disease risk. The objective of this study is to determine whether a specific brain regional pattern of disruption of WM integrity is shared by schizophrenia patients and their healthy siblings. We investigated brain white matter abnormalities by voxel-based analysis of white matter FA data acquired from diffusion tensor imaging in 34 pairs of schizophrenia patients and their healthy siblings, as well as in 32 healthy controls. Both schizophrenia patients and their healthy siblings showed reduced white matter FA in the left prefrontal cortex and the hippocampus in comparison to healthy controls, without significant difference between patients and siblings. In marked contrast, only schizophrenia patients exhibited reduced white matter FA in the left anterior cingulate cortex in comparison to both siblings and controls, without significant difference between siblings and controls. Thus, schizophrenia patients and their healthy siblings share disruption of WM integrity in the left prefrontal cortex and the hippocampus that may be related to higher risk of healthy siblings to develop schizophrenia, which may be eventually attributed to additional disruption of WM integrity in the left anterior cingulate cortex.
关键词	Schizophrenia Healthy Siblings Diffusion Tensor Imaging Fractional Anisotropy
资助者	Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L
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收录类别	SCI
语种	英语
资助者	Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L ; Funding for this study was provided by grants from the National Natural Science Foundation of China (30670752 to Zhening Liu) and Basic Research Program (973) from the Ministry of Science and Technology of China (2006CB500808 and 2007CB512300 to Zhening L
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/5927
专题	科研部门_学习记忆的分子神经机制（徐林）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zningl@163.com; shanbc@mail.ihep.ac.cn
作者单位	1.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, PR China 2.Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, PR China 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China 4.Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, PR Chin 5.Yale University School of Medicine, New Haven, CT, USA 6.National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, PR China
推荐引用方式 GB/T 7714	Hao YH,Yan Q,Liu HH,et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex[J]. SCHIZOPHRENIA RESEARCH,2009,114(37624):18-135.
APA	Hao YH.,Yan Q.,Liu HH.,Xu L.,Xue ZM.,...&shanbc@mail.ihep.ac.cn.(2009).Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex.SCHIZOPHRENIA RESEARCH,114(37624),18-135.
MLA	Hao YH,et al."Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex".SCHIZOPHRENIA RESEARCH 114.37624(2009):18-135.

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