| 其他摘要 | China is suffering from population aging with growing economy. Aging population costs more on medical and health care, while the health longevity population reduces the cost due to sparing age-related diseases. Their offspring also have low prevalence of age-related diseases. Hence, study on health longevity will improve the quality of life in aging population and also reduce social burdens. In China, it is difficult to collect perfect data about nonagenarians and centenarians because their distributions. Health statuses of long-lived people also bring the trouble to collect data. Until now, many studies are conducted in metropolises. In addition, the results in other populations shouldn´t accept without correction owning to the difference in life-style, area and race. Therefore, cross-sectional study of health status on longevity populations in both Sichuan and Yunnan provinces was conducted. Levels and common promoter SNPs of IL6, IL10 and TNFα were also done. All samples were divided into three groups by relationship: longevity group, sibship group and nonsibship group, and four groups by age: ≤59, 60-80, 90-94 and ≥95 years old. Generally, Glu increases with increasing age. High HDL-C, high ratio of HDL-C/TC，and lower levels of LDL-C, TC, Glu and TG take advantageous for extreme life. Glu and blood lipids in longevity group were lower than other groups. 90-94 group was lower than ≥95. No significant difference was found between genders within each age group. LDL-C in longevity was lower than other groups including age-groups in Dujiangyan area. LDL-C in ≥95 group was lower than 90-94. The female LDL-C in 90-94 was higher than ≥95, but no difference in male. Within 90-94, the level in female was higher than in male. The trends of change of TC and TG levels in Dujiangyan were inconsistent with these in Hongta area. Female TC and TG in 90-94 were higher than male in 90-94. HDL-C and HDL-C/TC were of inconsistency in the trend of changes between Dujiangyan and Hongta. After adjusting gender, female HDL-C/TC was greater than male within 90-94 group. Usually, IL6, IL10 and TNFα increased with growing age. Our data showed IL6, IL10 and TNFα were at basal level. IL6 level was higher than sibship and nonsibship group and no difference between genders within each group. No difference in TNFα was also found between groups. IL10 in longevity group was higher than nonsibship group. In many studies, il10-1082 and il6-174 loci have association with longevity and no association at tnfα-308 with longevity. No polymorphism was found at il6-174 from our Han samples. Allele frequency of il10-592A and -819T in male longevity group were higher than in male nonsibship group. The frequency of -238A and -308A was higher in longevity group than in nonsibship group, and the haplotype G-G lower. There were no differences after adjusting genders in -238 and -308 loci except haplotypes. Summarily, Glu and LDL-C were low in dujiangyan longevity group. Regional difference was observed in Glu and lipid profile. Han people have different loci of common SNPs in promoter region of IL6, IL10 and TNFα between longevity group and nonsibship group compared with other populations. |
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