| Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade | |
| Nie WH1; Fu BY2; O'Brien PCM2; Wang JH1; Su WT1; Tanomtong A3; Volobouev V4; Ferguson-Smith MA2; Yang FT*5; fy1@sanger.ac.uk | |
| 2008 | |
| 发表期刊 | BMC BIOLOGY
 |
| 卷号 | 6期号:X页码:e18 |
| 合作性质 | 其它 |
| 其他摘要 | Background: Flying lemurs or Colugos ( order Dermoptera) represent an ancient mammalian lineage that contains only two extant species. Although molecular evidence strongly supports that the orders Dermoptera, Scandentia, Lagomorpha, Rodentia and Primates form a superordinal clade called Supraprimates ( or Euarchontoglires), the phylogenetic placement of Dermoptera within Supraprimates remains ambiguous. Results: To search for cytogenetic signatures that could help to clarify the evolutionary affinities within this superordinal group, we have established a genome- wide comparative map between human and the Malayan flying lemur ( Galeopterus variegatus) by reciprocal chromosome painting using both human and G. variegatus chromosome-specific probes. The 22 human autosomal paints and the X chromosome paint defined 44 homologous segments in the G. variegatus genome. A putative inversion on GVA 11 was revealed by the hybridization patterns of human chromosome probes 16 and 19. Fifteen associations of human chromosome segments (HSA) were detected in the G. variegatus genome: HSA1/3, 1/10, 2/21, 3/21, 4/8, 4/18, 7/15, 7/16, 7/19, 10/16, 12/22 ( twice), 14/15, 16/19 ( twice). Reverse painting of G. variegatus chromosome-specific paints onto human chromosomes confirmed the above results, and defined the origin of the homologous human chromosomal segments in these associations. In total, G. variegatus paints revealed 49 homologous chromosomal segments in the HSA genome. Conclusion: Comparative analysis of our map with published maps from representative species of other placental orders, including Scandentia, Primates, Lagomorpha and Rodentia, suggests a signature rearrangement (HSA2q/21 association) that links Scandentia and Dermoptera to one sister clade. Our results thus provide new evidence for the hypothesis that Scandentia and Dermoptera have a closer phylogenetic relationship to each other than either of them has to Primates. |
| 资助者 | This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. ; This study was funded in part by the National Natural Science Foundation of China (to FY and WN) and a Wellcome Trust grant (to MAFS) as well as the award of a Royal Society international short visit (to WN). The authors are grateful to Christiane Denys and Tangliang Li for helping to col- lect G. variegatus materials. FY is currently an employee of the Wellcome Trust Sanger Institute. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/6380 |
| 专题 | 遗传资源与进化国家重点实验室_保护遗传学(细胞库) 遗传资源与进化国家重点实验室 |
| 通讯作者 | fy1@sanger.ac.uk |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, People's Republic of China 2.Cambridge Resource Centre for Comparative Genomics, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK 3.Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand 4.Muséum National d'Histoire Naturelle, Origine, Structure et Evolution de la Biodiversité, rue Buffon, 75005 Paris, France 5.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK |
| 推荐引用方式 GB/T 7714 | Nie WH,Fu BY,O'Brien PCM,等. Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade[J]. BMC BIOLOGY,2008,6(X):e18. |
| APA | Nie WH.,Fu BY.,O'Brien PCM.,Wang JH.,Su WT.,...&fy1@sanger.ac.uk.(2008).Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade.BMC BIOLOGY,6(X),e18. |
| MLA | Nie WH,et al."Flying lemurs – The 'flying tree shrews'? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade".BMC BIOLOGY 6.X(2008):e18. |
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| 2010111007.pdf（3330KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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