Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey

	Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey
	Li MH 1; Li SY 1,2; Xia HJ 1,2; Wang L 1,2; Wang YY 1,2; Zhang GH 1; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2007
发表期刊	VIROLOGICA SINICA
卷号	22 期号:6 页码:509-516
合作性质	其它
摘要	In the present research, two Chinese rhesus monkeys were inoculated intravenously with 5000 TCID50 of SIVmac239. The changes in the numbers of CD4+ T lymphocyte in peripheral blood, plasma viral loads, proviral DNA and humoral antibodies against virus were periodically monitored during 121 days. At the early stage of infection, proviral DNA had been detected in PBMCs, and infectious SIVmac239 virus had been isolated from PBMCs. At the same period, the numbers of CD4+ T lymphocytes were significantly decreased, and maintained at low level during the 121-day period of infection. Plasma viral loads reached the peak at week 2 post-inoculation and kept at a steady state subsequently. Moreover, antibodies against viral proteins were detected from plasma. All the results showed that the two Chinese rhesus monkeys had been infected with SIVmac239 successfully. This animal model can be applied for further AIDS researches.
关键词	Aids Siv Sivmac239 Hiv Primate Animal Model Chinese Rhesus Monkey
资助者	Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences.
收录类别	其他
语种	中文
资助者	Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences. ; Key Scientific and Technological projects of China (2004BA719A14) and Yunnan province (2004NG12, 2006PT08); National 973 project of China (2006CB504200, 2006CB504300); The Natural Science Foundation of China (30471605; 30671960); The Knowledge Innovation Program (KSCX1-YW-R-15) and “Western Light” Projects of Chinese Academy of Sciences.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6416
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Chin 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Li MH,Li SY,Xia HJ,et al. Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey[J]. VIROLOGICA SINICA,2007,22(6):509-516.
APA	Li MH.,Li SY.,Xia HJ.,Wang L.,Wang YY.,...&zhengyt@mail.kiz.ac.cn.(2007).Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey.VIROLOGICA SINICA,22(6),509-516.
MLA	Li MH,et al."Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey".VIROLOGICA SINICA 22.6(2007):509-516.

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