The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques

	The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques
	Xia HJ 1,2; Zhang GH 1; Wang RR 1; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2009
发表期刊	CELLULAR & MOLECULAR IMMUNOLOGY
卷号	6 期号:6 页码:433-440
合作性质	其它
摘要	Non-human primates such as Chinese rhesus macaques are the favorable models for preclinical study of potential therapeutic drugs, vaccines and mechanisms of human diseases. Little is known about the normal levels of leukocyte subpopulations of Chinese rhesus macaques. To obtain these data, 100 blood samples from Chinese rhesus macaques were collected. The normal range of major leukocyte subpopulations, such as T lymphocytes, B lymphocytes, monocytes, myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs), were quantitatively analyzed by flow cytometry through BD trucount tubes. The influence of age and sex on the cell counts of leukocyte subpopulations was analyzed. The counts of CD3(+)T cells, CD3(+)CD4(+)T cells, CD3(+)CD8(+)T cells and B cells decreased with age, but those of monocytes, mDCs and pDCs had no significant correlation with age. Significant differences existed in the cell counts of most leukocyte subpopulations between the male and female groups except pDCs. Furthermore the values of the females were higher than those of the males. The study provided basic information about the leukocyte subpopulations of Chinese rhesus macaques, and it may be valuable for immunobiological study of Chinese rhesus macaques. Cellular & Molecular Immunology. 2009;6(6):433-440.
关键词	Chinese Rhesus Macaque Leukocyte Subpopulation Absolute Count Age Sex
资助者	This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects.
收录类别	SCI
语种	英语
资助者	This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects. ; This work was supported in part by grants from Scientific and Technological Projects of China (2008ZX10001-002,2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029) and Yunnan (2006PT08), 973 Program (2006CB504208, 2009CB522306), the NSFC (30471605, 30671960, U0832601, 30872317), the CAS (KSCX1-YW-R-15, KSCX2-YW-R-185), and “Western Light” Projects.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6424
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
推荐引用方式 GB/T 7714	Xia HJ,Zhang GH,Wang RR,et al. The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2009,6(6):433-440.
APA	Xia HJ,Zhang GH,Wang RR,Zheng YT*,&zhengyt@mail.kiz.ac.cn.(2009).The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques.CELLULAR & MOLECULAR IMMUNOLOGY,6(6),433-440.
MLA	Xia HJ,et al."The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques".CELLULAR & MOLECULAR IMMUNOLOGY 6.6(2009):433-440.

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