| 其他摘要 | Some special environmental factors such as environmental enrichment (EE) and stress, affect broadly on some advanced cognitive functions of a brain. In addition, the monoamine system also plays important role in these advanced brain functions. Basing on the previous research, therefore, we did a series further research on the relationships between depression/anxiety and three environment factors, including EE, restraint stress (RS) and social status. Besides, we researched on the relationship between the β adrenergic receptor system and acquisition/retrieval of morphine- induced environment conditioned memory. In the first research work, we hypothesized that EE treatment after RS in the same day may reduce the depression-like and anxiety-like behaviors induced by the chronic RS in pre-adult mice. We, therefore, applied periods of 14 days’ and 28 days’ environments factors，and RS 4h/8h+EE 16h every day to create behaviors, which test by animal depression-like and anxiety-like behaviors model. Our conclusion is: 1) Chronic RS can inhabit the increase of body weight of pre-adult mice, and the same to that of the EE; 2) EE can inhibition the decrease of depression-like behavior induced by RS in the forced swimming test model, that is to say EE aggravates the depression-like behavior; 3) EE can increase the spontaneous exploring behavior, but can not affect the decrease of anxiety-like behavior induced by RS. Our another hypothesis was that depression-like individuals produced naturally in Macaca mulatta colony , which is one of the social statues primates, could mimic better individuals can produce more depressed ones; 2) The more density of monkey colony is, the more depressed individuals can be produced; 3) The tendency of the proportion of the depression in female monkey is more than that of male ones; 4) Some factors such as age, gender etc. could not be related to the proportion of the depression. In the last research work, there is not any report about whether β receptors play the role in the acquisition and retrieval of morphine-conditioned place preference (CPP) memories in mice. We, therefore, did research on the pharmacological effects of propranolol, one of the β receptors antagonists, on the acquisition and retrieval of cue memories in the morphine induced CPP. Our conclusion is that β receptor may not affect the acquisition, but enhance retrieval, which suggested that activating β receptor may strengthen the extinction of cue memories in morphine-CPP. |
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