| MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene | |
Shi L1,2; Li M1,2 ; Su B*1
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| 2012 | |
| 发表期刊 | GENE
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| 卷号 | 495期号:1页码:1-9 |
| 合作性质 | 其它 |
| 摘要 | MCPH1, a repressor of human telomerase reverse transcriptase (hTERT) function, is implicated in cellular immortalization. But little is known about how MCPH1 represses telomerase activity. In this study, to determine the mechanism by which MCPH1 regulates hTERT gene expression, we examined the role of MCPH1 in regulating the hTERT promoter in vitro. Co-transfection of the hTERT promoter with MCPH1 in Hela cells could inhibit the hTERT promoter activity. The EMSA assay demonstrated that MCPH1 could bind to the proximal hTERT promoter. Overexpression of MCPH1 could repress telomerase activity, and the repression was abolished by knocking down the MCPH1 expression using siRNA in U2OS cells. We propose that MCPH1 functions as a transcriptional repressor of hTERT in vitro. Since the activation of telomerase, widely observed in human tumor cell lines, is a critical step in tumorigenesis, our findings provide new insights into delineating the tumor-suppressing function of MCPH1 through its down-regulation of hTERT/telomerase expression |
| 关键词 | Microcephalin Transcriptional Repressor Telomerase Activity |
| 资助者 | This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). ; This work was supported by grants from the National 973 project of China (grant number, 2011CBA00401), the National Natural Science Foundation of China (grant numbers, 30871343 and 31071101), and the Natural Science Foundation of Yunnan Province of China (grant numbers, 2007C100M and 2009CD107). |
| WOS记录号 | WOS:000301163600001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/6901 |
| 专题 | 科研部门_比较基因组学（宿兵） 遗传资源与进化国家重点实验室 科研部门_转化基因组（李 明） |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China 2.Graduate School of Chinese Academy of Sciences, Beijing, PR China |
| 推荐引用方式 GB/T 7714 | Shi L,Li M,Su B*. MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene[J]. GENE,2012,495(1):1-9. |
| APA | Shi L,Li M,&Su B*.(2012).MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene.GENE,495(1),1-9. |
| MLA | Shi L,et al."MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene".GENE 495.1(2012):1-9. |
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| 2012040502.pdf（832KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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