Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice

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	Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice
	Wang YF 1,2; Wu J 1; Zhu B 1; Li CC 1; Cai JX*1; caijx@mail.kiz.ac.cn
	2012
发表期刊	STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
卷号	15 期号:2 页码:237-242
摘要	It is established that stress impairs spatial learning and memory via the hypothalamus-pituitary-adrenal axis response. Dopamine D1 receptors were also shown to be responsible for a stress-induced deficit of working memory. However, whether stress affects the subsequent emotional learning and memory is not elucidated yet. Here, we employed the well-established one-trial step-through task to study the effect of an acute psychological stress (induced by tail hanging for 5, 10, or 20 min) on emotional learning and memory, and the possible mechanisms as well. We demonstrated that tail hanging induced an obvious stress response. Either an acute tail-hanging stress or a single dose of intraperitoneally injected dopamine D1 receptor antagonist (SCH23390) significantly decreased the step-through latency in the one-trial step-through task. However, SCH23390 prevented the acute tail-hanging stress-induced decrease in the step-through latency. In addition, the effects of tail-hanging stress and/or SCH23390 on the changes in step-through latency were not through non-memory factors such as nociceptive perception and motor function. Our data indicate that the hyperactivation of dopamine D1 receptors mediated the stress-induced deficit of emotional learning and memory. This study may have clinical significance given that psychological stress is considered to play a role in susceptibility to some mental diseases such as depression and post-traumatic stress disorder.
关键词	Dopamine D1 Receptor Emotional Memory Mice Stress Sch23390
资助者	This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai.
收录类别	SCI
语种	英语
资助者	This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai. ; This work was supported by the National Basic Research Program (G1999054000) and the National Natural Sciences Foundation of China (30070251) to Dr Jingxia Cai.
WOS记录号	WOS:000299504300012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6909
专题	科研部门_发育生物学（毛炳宇）其他
通讯作者	caijx@mail.kiz.ac.cn
作者单位	1.Section of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, PR China 2.Graduate School of the Chinese Academy of Sciences, Beijing, PR China
推荐引用方式 GB/T 7714	Wang YF,Wu J,Zhu B,et al. Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice[J]. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,2012,15(2):237-242.
APA	Wang YF,Wu J,Zhu B,Li CC,Cai JX*,&caijx@mail.kiz.ac.cn.(2012).Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice.STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS,15(2),237-242.
MLA	Wang YF,et al."Dopamine D1 receptors are responsible for stress-induced emotional memory deficit in mice".STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS 15.2(2012):237-242.

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