NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons

	NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons
	Fu Y 1,3; He F 3,4,5; Tang NLS 2,3; Tam CWC 1; Lui VWC 1; Chiu HFK 1; Lam LCW*1; cwlam@cuhk.edu.hk
	2012
发表期刊	ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷号	26 期号:1 页码:88-90
摘要	Neural precursor cell expressed, developmentally down-regulated (NEDD9) gene was a new candidate risk gene for Alzheimer disease (AD). The CC genotype of a single nucleotide polymorphism rs760678 within this gene was associated with increasing risk of AD in a large study with white population. Our study aimed to replicate the initial report in Chinese population and explore its effect on cognitive performance. A total of 262 patients with AD, 293 patients with mild cognitive impairment, and 434 cognitive intact controls were recruited in the study. The result showed that G allele had a greater risk of AD (chi(2) for trend test = 5.61, df 1, P = 0.018). The effects were mainly observed among Apolipoprotein E (APOE) epsilon 4 noncarriers (chi(2) for trend test = 4.30, df 1, P = 0.038). After adjustment of sex, age, education year, and APOE e4 status by logistic regression, significant association between NEDD9 GG genotype and AD remained [OR = 2.04, 95% confidence interval (CI) = 1.02-4.08, P = 0.044]. The scores of Cantonese version of the Mini-mental State Examination and Alzheimer's Disease Assessment Subscale-Cognitive subscale were associated with N polymorphism after adjusting for sex, age, education year, and ApoE epsilon 4 status (Linear regression model, P < 0.05). Our study identified rs760678 within NEDD9 gene in association with the risk of AD and cognitive performance in Chinese older persons. The fact that different alleles accounted for the risk in different population might suggest that there were ethnic group specific haplotypes that were primarily responsible for the predisposition.
关键词	Parkinsons-disease Association Onset
收录类别	SCI
语种	英语
WOS记录号	WOS:000300639800013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6912
专题	遗传资源与进化国家重点实验室科研部门_分子进化与基因组多样性（张亚平）
通讯作者	cwlam@cuhk.edu.hk
作者单位	1.Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China 2.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Beijing 100864, Peoples R China 5.KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Fu Y,He F,Tang NLS,et al. NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons[J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS,2012,26(1):88-90.
APA	Fu Y.,He F.,Tang NLS.,Tam CWC.,Lui VWC.,...&cwlam@cuhk.edu.hk.(2012).NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons.ALZHEIMER DISEASE & ASSOCIATED DISORDERS,26(1),88-90.
MLA	Fu Y,et al."NEDD9 Gene Polymorphism Influences the Risk of Alzheimer Disease and Cognitive Function in Chinese Older Persons".ALZHEIMER DISEASE & ASSOCIATED DISORDERS 26.1(2012):88-90.

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