Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

	Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro
	Fan LL 1; Huang N 2,3; Yang RG 1; He SZ 1; Yang LM 2; Xu H1; Zheng YT2; orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn
	2012
发表期刊	LETTERS IN DRUG DESIGN & DISCOVERY
卷号	9 期号:1 页码:44-47
合作性质	其它
摘要	In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 mu g/mL, and TI values of 63.76 and 53.60, respectively.
关键词	5 6-dihydro-indolo[1 2-a]Quinoxaline Acquired Immunodeficiency Syndrome Human Immunodeficiency Virus-1 Inhibitor
资助者	This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006).
收录类别	SCI
语种	英语
资助者	This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006). ; This work was financially supported in part by grants from New Century Excellent University Talents, State Education Ministry of China (NCET-06-0868), and the Special Funds of Central Colleges Basic Scientific Research Operating Expenses (QN2009045). We also would like to acknowledge the National Basic Research Program of China (2009CB522306), the Eleventh Five-Year Key Scientific and Technological Program of China (2009ZX09501-029) and Yunnan Province (2007BC006).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6917
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn
作者单位	1.Laboratory of Pharmaceutical Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, P. R. China 2.Key Laboratory of Animal Models and Human Diseases Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 3.Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China
推荐引用方式 GB/T 7714	Fan LL,Huang N,Yang RG,et al. Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2012,9(1):44-47.
APA	Fan LL.,Huang N.,Yang RG.,He SZ.,Yang LM.,...&orgxuhui@nwsuaf.edu.cn, zhengyt@mail.kiz.ac.cn.(2012).Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro.LETTERS IN DRUG DESIGN & DISCOVERY,9(1),44-47.
MLA	Fan LL,et al."Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro".LETTERS IN DRUG DESIGN & DISCOVERY 9.1(2012):44-47.

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