| Evaluating the Phylogenetic Position of Chinese Tree Shrew (Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome: Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research | |
| Xu L1,2; Chen SY3; Nie WH4; Jiang XL4; Yao YG*1; ygyaozh@gmail.com | |
| 2012 | |
| 发表期刊 | JOURNAL OF GENETICS AND GENOMICS
 |
| 卷号 | 39期号:3页码:131-137 |
| 合作性质 | 其它 |
| 摘要 | Tree shrew (Tupaia belangeri) is currently placed in Order Scandentia and has a wide distribution in Southeast Asia and Southwest China. Due to its unique characteristics, such as small body size, high brain-to-body mass ratio, short reproductive cycle and life span, and low-cost of maintenance, tree shrew has been proposed to be an alternative experimental animal to primates in biomedical research. However, there are some debates regarding the exact phylogenetic affinity of tree shrew to primates. In this study, we determined the mtDNA entire genomes of three Chinese tree shrews (T. belangeri chinensis) and one Malayan flying lemur (Galeopterus variegatus). Combined with the published data for species in Euarchonta, we intended to discern the phylogenetic relationship among representative species of Dermoptera, Scandentia and Primates. The mtDNA genomes of Chinese tree shrews and Malayan flying lemur shared similar gene organization and structure with those of other mammals. Phylogenetic analysis based on 12 concatenated mitochondrial protein-encoding genes revealed a closer relationship between species of Scandentia and Glires, whereas species of Dermoptera were clustered with Primates. This pattern was consistent with previously reported phylogeny based on mtDNA data, but differed from the one reconstructed on the basis of nuclear genes. Our result suggested that the matrilineal affinity of tree shrew to primates may not be as close as we had thought. The ongoing project for sequencing the entire genome of Chinese tree shrew will provide more information to clarify this important issue. |
| 关键词 | Chinese Tree Shrew Mtdna Phylogeny Animal Model Flying Lemur |
| 资助者 | This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). ; This work was supported by grants from Chinese Academy of Sciences (Nos. KSCX2-EW-R-11 and KSCX2-EW-J-23), the National 863 Project of China (No. 2012AA021801), and Yunnan Province (No. 2009CI119). |
| WOS记录号 | WOS:000302141000003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/6921 |
| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚） 科研部门_动物模型与人类重大疾病机理重点实验室 遗传资源与进化国家重点实验室 遗传资源与进化国家重点实验室_保护遗传学(细胞库) 科研部门_兽类生态与进化（蒋学龙） |
| 通讯作者 | ygyaozh@gmail.com |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Ya’an, Sichuan 625014, China 4.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Xu L,Chen SY,Nie WH,et al. Evaluating the Phylogenetic Position of Chinese Tree Shrew (Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome: Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research[J]. JOURNAL OF GENETICS AND GENOMICS,2012,39(3):131-137. |
| APA | Xu L,Chen SY,Nie WH,Jiang XL,Yao YG*,&ygyaozh@gmail.com.(2012).Evaluating the Phylogenetic Position of Chinese Tree Shrew (Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome: Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research.JOURNAL OF GENETICS AND GENOMICS,39(3),131-137. |
| MLA | Xu L,et al."Evaluating the Phylogenetic Position of Chinese Tree Shrew (Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome: Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research".JOURNAL OF GENETICS AND GENOMICS 39.3(2012):131-137. |
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