Effect of morphine on conditioned place preference in rhesus monkeys

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	Effect of morphine on conditioned place preference in rhesus monkeys
	Wang JH1; Wu XJ 1,2; Li CY 1; Wei JK 1,2; Jiang HH 1,2; Liu CR 1,2; Yu CY 1; Carlson S 3,4,5; Hu XT 1,6; Ma H 1,2; Duan W 1; Ma YY1,6; wjh16@hotmail.com ; yuanma0716@vip.sina.com
	2012
发表期刊	ADDICTION BIOLOGY
卷号	17 期号:3 页码:539-546
合作性质	其它
摘要	In rodents, a conditioned place preference (CPP) can be induced by morphine. In the current study, we designed a biased place conditioning paradigm to test the rewarding effects of morphine in freely moving rhesus monkeys. Five monkeys were first placed in three serial rooms with the doors open between them for three days. After this habituation period, during which baseline preference for each of the two end rooms was measured, CPP conditioning occurred when the monkeys were injected intramuscularly with morphine at an increasing dose (1.5, 3, 4.5 mg/kg) before they entered the non-preferred room and on alternate days, with saline before they entered the preferred room. Morphine and saline treatment lasted for six days, respectively. CPP was tested 24 hours after the end of CPP training. The result showed that in all five monkeys, CPP was induced by the morphine treatment. The preference lasted for at least 15.3 +/- 1.7 months.
关键词	Addiction Conditioning Memory Morphine Place Preference Rhesus Monkey
资助者	The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412).
收录类别	SCI
语种	英语
资助者	The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412). ; The authors thank Dr Ilkka Linnankoski and Prof Jean- François Riou for revising the language. This study was supported by National Science Foundation of China the Academy of Finland (National Center of Excellence 2006-11 and the Neuro Program 214412).
WOS记录号	WOS:000302998400004
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6944
专题	认知障碍病理学科研部门_神经系统编码（胡新天）
通讯作者	wjh16@hotmail.com; yuanma0716@vip.sina.com
作者单位	1.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, China 2.Graduate School of Chinese Academy of Sciences, China 3., Institute of Biomedicine/Physiology, University of Helsinki, Finland 4.Medical School, University ofTampere, Finland 5.Aalto University School of Science andTechnology, Finland 6.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, China
推荐引用方式 GB/T 7714	Wang JH*,Wu XJ,Li CY,et al. Effect of morphine on conditioned place preference in rhesus monkeys[J]. ADDICTION BIOLOGY,2012,17(3):539-546.
APA	Wang JH*.,Wu XJ.,Li CY.,Wei JK.,Jiang HH.,...&yuanma0716@vip.sina.com.(2012).Effect of morphine on conditioned place preference in rhesus monkeys.ADDICTION BIOLOGY,17(3),539-546.
MLA	Wang JH*,et al."Effect of morphine on conditioned place preference in rhesus monkeys".ADDICTION BIOLOGY 17.3(2012):539-546.

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