Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family

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	Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family
	Luo S 1; Zhang Y 1; Hu QX 1; Chen JJ 1; Li KP 1; Lu C 1; Liu H 2; Wang W 2; Kuang HH*1; kuangfile@gmail.com
	2012
发表期刊	PLANT PHYSIOLOGY
卷号	159 期号:1 页码:197-210
摘要	The proper use of resistance genes (R genes) requires a comprehensive understanding of their genomics and evolution. We analyzed genes encoding nucleotide-binding sites and leucine-rich repeats in the genomes of rice (Oryza sativa), maize (Zea mays), sorghum (Sorghum bicolor), and Brachypodium distachyon. Frequent deletions and translocations of R genes generated prevalent presence/absence polymorphism between different accessions/species. The deletions were caused by unequal crossover, homologous repair, nonhomologous repair, or other unknown mechanisms. R gene loci identified from different genomes were mapped onto the chromosomes of rice cv Nipponbare using comparative genomics, resulting in an integrated map of 495 R loci. Sequence analysis of R genes from the partially sequenced genomes of an African rice cultivar and 10 wild accessions suggested that there are many additional R gene lineages in the AA genome of Oryza. The R genes with chimeric structures (termed type I R genes) are diverse in different rice accessions but only account for 5.8% of all R genes in the Nipponbare genome. In contrast, the vast majority of R genes in the rice genome are type II R genes, which are highly conserved in different accessions. Surprisingly, pseudogene-causing mutations in some type II lineages are often conserved, indicating that their conservations were not due to their functions. Functional R genes cloned from rice so far have more type II R genes than type I R genes, but type I R genes are predicted to contribute considerable diversity in wild species. Type I R genes tend to reduce the microsynteny of their flanking regions significantly more than type II R genes, and their flanking regions have slightly but significantly lower G/C content than those of type II R genes.
资助者	This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.).
收录类别	SCI
语种	英语
资助者	This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.). ; This workwassupportedby the 973 NationalKey BasicResearch Program (grant no. 2009CB119000), a China Transgenic Grant (grant no. 2009ZX08009–045B), the Natural Science Foundation of China (grant no. 30921002), the Key Laboratory of Plant Germplasm En- hancement and Specialty Agriculture, Chinese Academy of Sciences (to J.C.), and the Ministry of Agriculture of China (grant no. 2009ZX08009–021B to W.W.).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6956
专题	基因起源组
通讯作者	kuangfile@gmail.com
作者单位	1.Key Laboratory of Horticulture Biology, Ministry of Education, and Department of Vegetable Crops, College of Horticulture and Forestry, Huazhong Agricultural University, Wuhan, People’s Republic of China, 430070 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People’s Republic of China, 650223
推荐引用方式 GB/T 7714	Luo S,Zhang Y,Hu QX,et al. Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family[J]. PLANT PHYSIOLOGY,2012,159(1):197-210.
APA	Luo S.,Zhang Y.,Hu QX.,Chen JJ.,Li KP.,...&kuangfile@gmail.com.(2012).Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family.PLANT PHYSIOLOGY,159(1),197-210.
MLA	Luo S,et al."Dynamic Nucleotide-Binding Site and Leucine-Rich Repeat-Encoding Genes in the Grass Family".PLANT PHYSIOLOGY 159.1(2012):197-210.

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